中医药在调控5-羟色胺治疗阻塞性睡眠呼吸暂停中的研究进展

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【关键词】 阻塞性睡眠呼吸暂停；5-羟色胺；中医药；信号通路；作用机制 【中图分类号】R259 【文献标志码】A 【文章编号】1007-8517（2025）21-0050-09 DOI：10.3969/j.issn.1007-8517.2025.21.zgmzmjyyzz202521011

Abstract：Obstructivesleepapneaisaslepbreathingdisordercharacterizedbyrepeatedupperairwayobstructionandapnea duringsleep.Itsincidencehasbenincreasingyearly，makingitasignificantpublichealthissue.Studieshaveshownthatthe 5-hydroxytryptamine（5-HT）systemservesasanessntial“regulator”ofvariousphysiologicalfunctions，includingrespiratory rhythmcontrol，maintenanceofupperairaymuscletone，regulationofrespiratorymuscleactivityndoxygensensing.Dyfunctioof the 5-HT system may beoneofthe key mechanisms underlying the developmentofobstructive sleep apnea.Traditional Chinese Medicine（TCM）ofersamulti-targettherapeuticapproachtoobstructivesleepapneabyregulatingthesynthesis，release，andeceptor expression of 5-HT ，effectively improving the clinical symptoms and pathological changes in obstructive sleep apnea patients.Therefore，systematicalleviewingtheoleofte5-HTsignalingpathwayinthpathogeesisofobstructiveslepapeaandfurtherexplo ring the mechanisms and current status of how TCM monomers，TCM formulas，and external TCMtherapies regulate the 5-HT system couldprovidevaluable insightsandabasisforresearchandthepreventionandtreatmentofobstructiveslepapnea using TCM.

KeyWords：ObstructiveSleepApnea;5-hydroxytryptamine；TraditionalChinese Medicine；SignalingPathway；Mechanismof Action

阻塞性睡眠呼吸暂停（obstructive sleep apnea，OSA）是一种以睡眠期间反复出现完全或不完全上气道阻塞为特征的呼吸障碍性疾病。（剩余17147字）