机器人辅助腹腔镜手术联合醋酸甲羟孕酮治疗子宫内膜癌的临床研究

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中图分类号 R737.33 文献标识码A文章编号 2096-7721（2025）07-1162-07

AbstractObjective：Toinvestigatetheeficacyofrbot-assistedlaparoscopicsurgerycombinedwithmedroxyprogesteroneacetatein thetreatmentofendometrialcancer （EC）.Methods：Aretrospectivestudywasconductedn8OECpatientsadmitedtoWuhanirst HospitalfromJauay1toJue4Basdondifentreamentmethdsnolledpatisediidedtoheoolgroup（8， receivingtradoallaparospicsrgery）andthsevatiogoup（n=42eivingbotasstedlaparosopicsrgery）Bothoupf patientswereoralladministeedmdroxyprogesteroneacetatetablts （.5gachtieoedaily）startingfropostoperativeda5，and themedictionwasontiuedfor18Odays.Perioperativeindicators，ostoperativecomplications，andrecurencerateswereompared betwenthetwogoups.Tumorarkers，tumormetastasis-relatedmolecules，inflammatorycytokines，andimmunefunctinidicators weremeasuredbefore surgeryand7dayspostoperatively. Qualityoflifewasasesedusing theEuropean OrganizationforResearch and TreatmentofCancer QualityofLife Questionnaire（EORTCQLQ-C30）beforesurgeryand180days postoperatively.Results：The operative time in the observation group was significantly longer than that in the control group （ P <0.05），while intraoperative blood loss and postoperative exhaust time were significantly shorter （ P <0.05）. On postoperative day 7， levels of tumor markers， tumor metastasisrelatedmolecules，ndinflammatorycytokinesinthebservationgroupweresignificantlylowerthanthoseinthecontrolgroup（ P <0.05）. There was no significant difference in postoperative complication rates or recurrence rates between the two groups （ P >0.05）. At 180 days postoperativelytebsevationgoupadsigicantlyhigherfunctioalstatusscorsandsigfcantlylowersymptomsoescopadto the control group . Conclusion： Robot-asssted laparoscopic surgery combined with medroxyprogesterone acetate can ffectively reduceintraopativelod，srnopatiesttiupprssumorakersdastasis-eadoleulvte inflammatoryesponses，improvepostoperativeimmunefunction，andignificantlyancepatients’qualityof ifewithighsafety. Key WordsEndometrial Cancer; Robot-assisted Surgery; Laparoscopic Surgery; Medroxyprogesterone Acetate

子宫内膜癌（EndometrialCancer，EC）是女性生殖系统常见恶性肿瘤[1]，其典型临床表现为绝经后或围绝经期不规则阴道出血，可通过简便准确的子宫内膜病理学检查实现早期诊断，多数患者可于疾病早期确诊[2]。（剩余10032字）