植物乳杆菌X86对大鼠子代早期发育和肠道菌群的影响

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中图分类号：S816.7 文献标志码：A 文章编号：0366-6964（2025）10-5315-13

Abstract： The aim of this study was to investigate the effects of maternal supplementation with Lactiplantibacillus plantarum X86 during pregnancy and lactation on early ofspring development and gut microbiota. Sixteen gregnant SD rats were selected and divided into control group （ ） and L . plantarum X86 group （ ）.Ratsin the L . plantarumX86 group were given Lactiplantibacillus plantarumX86 gavage from late pregnancy until early lactation. The impact on offspring growth，intestinal barrier function，and gut bacterial community structure were evaluated by various indexes. Results showed that L . plantarum X86 supplementation increased body weight at 7 and 14 days of age，and elevated heart and liver coefficients of the offspring；However，it reduced the white blood cell counts and hemoglobin content. Additionally，L. plantarum X86 supplementation downregulated IL=6mRNA expression and upregulated Occludin mRNA expression in the intestines of rat offspring. 16SrRNA sequencing analysis revealed that the maternal supplementation with L . plantarum X86 during late pregnancy and lactation significantly altered the gut microbiota in rat offspring， increasing the relative abundance of Lactobacillus and Romboutsia while reducing that of Escherichia-Shigella，Staphylococcus ，and Akkermansia. A broad reduction in KEGG metabolic pathway abundance was also observed. In conclusion，consumption of L . plantarum X86 during late pregnant and early lactation promotes offspring growth and development，and exerts beneficial effects on the gut barrier function and bacterial microbiota composition.

Keywords： Lactiplantibacillus plantarum X86； pregnancy and lactation period; rat offsprings; growth and development;gut microbiota

∗ Corresponding author： XIE Xiulan，E-mail： xiexiulan99@163.com

在妊娠和哺乳期间，母亲不仅通过胎盘和母乳提供营养，还向子代输送大量的生物活性成分，对其生长发育和免疫系统的成熟具有重大影响[1]。（剩余19338字）