种养循环模式中黏菌素抗性基因mcr-1的归趋

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中图分类号：S851 文献标志码：A 文章编号：0366-6964（2025）10-4851-12

Abstract：The resistance gene mcr-1，as a key genetic element mediating bacterial resistance to "last-resort”antibiotic colistin，has become a research hotspot since its discovery and poses a potential threat to public health. This paper aims to investigate the fate of colistin resistance gene mcr-l in the planting-breeding cycling system. First，we summarize the resistance mechanisms， horizontal gene transfer， fitness costs，and compensatory evolution of mcr-1. Subsequently，we examine its occurrence，fate，and horizontal transmission characteristics in the planting-breeding cycling system，along with the key factors influencing its dissemination. Finally，we propose corresponding control measures， providing insights for high-quality development of circular agriculture and public health security.

Keywords： crop-livestock integrated farming system; antibiotic resistance gene; mcr-l; fate; horizontal gene transfer；colistin

∗ Corresponding author：WU Yinbao，E-mail： wuyinbao@ scau. edu. cn

种养循环模式作为一种生态友好型的农业生产方式，通过有效利用畜禽粪污为土壤提供养分，促进了农业的可持续发展[1]。（剩余28117字）