整合eQTL和GWAS数据识别潜在功能基因位点在动物遗传育种中的研究进展

打开文本图片集

中图分类号：S813.3 文献标志码：A 文章编号：0366-6964（2025）10-4759-15

Abstract： Accurately identifying the potential functional genetic loci that significantly associated with animal economic traits holds both theoretical and practical significance for improving individual animal breeding outcomes and enhancing production performance. With the advancement of omics technologies，integrating multi-omics information has become an effective strategy to enhance the precision of genetic locus identification. Among these，expression quantitative trait locus （eQTL） analysis provides a new research perspective for analyzing the association mechanisms between genotypes and economic traits，as well as the genetic regulatory networks of gene expression，making it an important research direction in the post-genome-wide association study （Post-GWAS） era. This paper first introduces the basic principles and methods of eQTL analysis，then focuses on strategies and approaches for integrating eQTL and GWAS data to enhance the eficiency of functional genetic loci identification，as well as its applications in the genetic breding of important livestock （cattle， pigs，chickens and sheep）. Finally，it summarizes the problems that exist in practical implementation，which provides theoretical foundations for elucidating the genetic architecture of complex traits in animals and establishes a crucial basis for advancing innovative biobreeding technologies to revitalize the livestock breeding industry.

Keywords：eQTL;GWAS;functional genetic loci;animal breeding ∗ Corresponding author： WANG Zhiying，E-mail： wzhy0321@126.com

动物育种的核心目标是通过改良经济性状来提升生产性能，从而满足日益增长的畜产品需求。（剩余30993字）