布鲁氏菌脂多糖的生物合成及其在免疫逃逸中的生物学功能

打开文本图片集

中图分类号：R378.5 文献标志码：A 文章编号：0366-6964（2025）10-4863-14

Abstract： Brucellosis is a zoonotic bacterial disease caused by Brucella spp.，which poses a serious threat to human health and the development of the livestock industry. Brucella is an intracellular pathogen，and its ability to evade the host's inate immune response and survive within host cells is a key aspect of its virulence. Lipopolysaccharide （LPS） is one of the major virulence factors encoded by Brucella. Compared to other Gram-negative bacteria，the main components， spatial structure，and linkage of Brucella LPS are distinct，which results in its unique low endotoxicity. Moreover，Brucella LPS plays a crucial role in helping the bacteria evade recognition by the host's immune system and in modulating immune responses. This review focuses on Brucel LPS， reviewing its unique structure，biosynthesis process，and immune evasion mechanisms，thereby laying the foundation for a comprehensive understanding of the biological functions of Brucella LPS.

Keywords： Brucella ; lipopolysaccharides; intracellular survival; immune evasion ∗ Corresponding authors：LI Peng，E-mail： lipengO1 caas.cn;DING Jiabo，E-mail：dingjiabo @ caas.cn

布鲁氏菌病（brucellosis）是由布鲁氏菌（Bru-ceaspp.）引起的一种重要的人畜共患细菌病，对人类健康和畜牧业发展构成巨大威胁[1]。（剩余34387字）