霍山石斛颗粒抗电离辐射损伤研究

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关键词霍山石斛颗粒；电离辐射损伤；体液免疫系统；血液系统；自由基；抗氧化

中图分类号R285文献标识码A

文章编号 0517-6611（2025）20-0158-04

doi：10.3969/j.issn.0517-6611.2025.20.035

Abstract[Objective]To observe the protective effect of Dendrobium huoshanense granules on mice irradiated by -rays.[Method]A totalf20healthymaleSPF-gradeF1generationmicewererandomlydividedinto3majorgroupsbasedonbodyweightEachmajorgroupwas furtherdividedito4dosegroupsitOmiceineachdosegroup.Thcontrolgroupsgivenpurifedwaterhileteothergroupseread ministered low[ 0.75g/（kg⋅d）] ，medium[ 1.50g/（kg⋅d）] ，and high [4.50g/（kg⋅d）] doses of the test sample via continuous gavage for 14 das.Afterwadslicbeodatstlseodstialil count，SODatityandsruemolysinlvelsweremeasdatdierentsaplingtis.Result]Onth3dnd4thysposadi， the white blood cell count in the 4.50g/（kg⋅d） group was significantly higher than that in the control group.Additionally，the SOD activity in the serum of mice in the 4.50g/（kg⋅d） group on the 7th day post-irradiation was significantly higher than that in the control group （ P<0.05 ）. [Conclusion]Dendrobiumhuoshanensegranuleshaveacertainprotectiveefectonmice withioningradiationijury.Themechanismmaybe relatedtotherotetiooftlooddmralinesessellsteacementoftioidantactivitytoavengfrdicals.

KeywordsDendrobiumhuoshanensegranules;Ionizingradiationijury;Humoralimmunesyste;Bloodsystem;Freeradicals;Atioxidant

人们在日常生活中会受到各种来源电离辐射的危害及影响，如医院诊疗中的CT扫描、X射线拍片 ⋅γ 射线放疗，核行业作业、宇航员航天作业和采矿作业中接触的放射性物质辐射；此外，近年日本核污水排海事件因含有大量放射性物质，对人体健康构成巨大威胁，也引起了广泛关注。（剩余8389字）