胆管细胞衰老在胆汁淤积性肝病中的作用机制及其靶向治疗进展

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通信作者：刘延鑫，liuyanxin@126.com（ORCID：0009-0009-2649-9659）

基金项目：国家自然科学基金面上项目（82074340）；河南省中医药科学研究专项重点项目（2024ZY1030）

Mechanism of action of cholangiocyte senescence in cholestatic liver diseaseand retated targeted therapies

XU Huaming Ia，Ib ，YANG Liub， YAN Wuling²， ZHENG Sijialb， YANG Nianlb，LIU Yanxinla

1.a.MedicalCollege，b.CollgeofTraditionalChineseMedicine，Henan UniversityofChineseMedicine，Zhengzhou450046， China;2.DepartmentofPathology，TheThirdAfliatedHospitalofHenanUniversityofChineseMedicine，Zhengzhou4008， China

Correspondingauthor：LIU Yanxin， liuyanxin@126.com（ORCID：0009-0009-2649-9659）

Abstract：Cholestatic liverdisease（CLD）isaliverconditioncausedbydisorders in bileacid secretionandmetabolismdueto variousreasons，andithasthecommonpathological featuresofvariouschronicliverdiseases.Inrecentyears，theroleof cholangiocytesenescence（CS）inthe pathogenesisofCLDhasatractedmoreandmoreattention，andCS notonlyparticipates in thedevelopmentandprogresionofCLD，butitisalsosignificantlyassociatedwiththecourseandprognosisof thedisease. Targetedclearanceofsenescentcholangiocytesorblockingsenescence-relatedpathwayscanimproveCLD.Thisarticlesummarizes theroleofCSinCLD，relatedinfluencingfactors，andtheresearchadvancesinCLD，inordertoprovideatheoreticalreferecefor subsequent studies on CLD.

KeyWords：Cholestasis；Cholangiocytes；Cellular Senescence

Researchfunding：NationalNaturalSienceFoundationofChina GeneralProject（82O7434O）；KeyProgramofTraditionalChinese MedicineScientificResearch inHenanProvince（2O24ZY1030）

胆汁淤积性肝病（cholestaticliverdisease，CLD）是一组以慢性胆汁淤积和免疫介导的胆道损伤为特征的肝脏疾病，其发病机制复杂，涉及毒性胆汁酸蓄积、胆管反应、炎症、应激、纤维化和细胞衰老等核心因素。（剩余20046字）