PINK1/Parkin信号通路介导的线粒体自噬在代谢相关脂肪性肝病中的作用及靶向治疗研究进展

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通信作者：朱小灯，271501247@qq.com（ORCID：009-0008-5821-5772）；李开楊，1592877812@qq.com（ORCID：0009-0000-3276-6295）

Role of mitophagy inducedby thePTEN-induced kinase 1/Parkin signaling pathway in metabolic associated fatty liverdiseaseandrelatedadvancesintargetedtherapies

ZHUShengjin’，ZHUXiaodeng²，LI Kaiyang³，YANGMeil，WUXian4

1.DepartmentofClinicalLaboratory，heScondAfiliatedHospitalofGuzhouUniveritofTraditionalChineseMedicine，Guiang 550001，China;2.DepartmentofClinicalLaboratory，GuzhouHospital，Beijing JshuitanHospital，Guiang5504，ina; 3.TheSecondClinicalMedicalShoolofGuizhouUniversityofTrditionalChineseMedicine，uiyang55oo2，Chin;4.Pratal Diagnosis Center， Guizhou Provincial People's Hospital， Guiyang 55ooo2， China

Corresponding authors：ZHU Xiaodeng，271501247@qcom（0RCID：0009-008-5821-5772）；LIKaiyang，1592877812@qq. com （ORCID：0009-0000-3276-6295）

Abstract：Metabolicassociatedfatty liverdisease（MAFLD）hasacomplexpathogenesis，andmitophagyisinvolvedinthe developmentand progresionof MAFLDandplaysakeyroleinliver metabolicpathwaysandsignaling networks.Mitophagyis regulatedbyavarietyof pathways，andthePTEN-induced kinase1（PINK1）/Parkinpathwayisconsideredthe mainpathway for regulating mitophagy.MitophagymediatedbythePINKl/Parkinpathwaycanregulate lipidmetabolism，inflammation，andfibrosis anddelaytheprogressonofMAFLD.ThisarticlereviewstheroleofmitophagymediatedbythePINK1/ParkinpathwayinMAFLDand theresearchadvancesintargetedtherapy，inordertoprovidetheoreticalbasesandideasforthepreventionandtreatmentofMAFD.

Key Words：Metabolism-Associated Fatty Liver Disease；Mitophagy；PINK1/Parkin Signaling Pathway

Research funding：NationalNaturalScienceFoundationofChina（82160866）；Scienceand TechnologyFoundationof Guizhou Health Commission（gzwkj2023-208）

非酒精性脂肪性肝病（non-alcoholic fatty liver disease，NAFLD）/代谢相关脂肪性肝病（metabolism-associated fattyliverdisease，MAFLD）是肝细胞中脂肪过量沉积而导致的慢性肝病[1]。（剩余18388字）