核因子KB信号通路调控铁死亡的机制及在肝脏疾病中的作用

打开文本图片集

基金项目：河南省中医药科学研究专项课题（2022ZY1167，2024ZY2156）；全国名中医传承工作室建设项目（国中医药办人教函[2018]119号）

Mechanism of the nuclear factor-kappa Bsignaling pathwayregulating ferroptosis and its role in liver diseases

CHENG Xinyueä，SHI Wenjieä，LIU Ronga，LU Baopinga，b

a.TheSecondClicaledicalColege，b.situteofHepatology，enanUniversityofineseedicine，Zhengzhou4o4in

Corresponding author：LU Baoping，lbp1921@sohu.com （ORCID：0000-0002-3707-2185）

Abstract： As a classical inflammatory response pathway，the nuclear factor-kappa B （NF- κB ） signaling pathway plays a critical roleinvariousphsiologicalandpathologicalprocees.Ferroptosisisewforofo-apoptoticcelldeathandreetdies have shown that there is a strong link between the NF- κB signaling pathway and ferroptosis，which affects the development and progresionofliverdiseases.Therefore，regulationofferoptosisbytargetingtheNF-Bsignalingpathwayhasageatpotentialin the treatment of liver diseases.This article discusses the influence of the NF- κB signaling pathway on the critical links such as lipid metabolismandironmetabolismduringferroptosis，aswellasitsmechanismofactioninthepositiveandnegativergulationof ferotosis.Meanwhile，thisarticlereviewstheresearchadvancesintheroleofthissignalingpathwayinliverdiseasessuchaliver injury，noncoicfttlivedsease，lolicliverdase，ndhepatoellaraiothroughhgulatioffoptoss，o to provideareferenceforfurterunderstandingoftepathogenesisofiverdiseasesandthedevelopmentofnewterapeuticstategies.

Keywords：NuclearFactor-kB；Ferroptosis；LiverDiseases

Research funding：The SpecialResearch Projectof TraditionalChinese Medicinein Henan Province（2O2ZY167，2O24ZY2156）; NationalFamous Traditional ChineseMedicinePractitionerInheritance WorkshopConstructionProject（National ChineseMedicine Office Human Education Letter[2018］No.119）

肝脏作为人体重要的代谢器官，承担着众多关键生理功能。（剩余23348字）