肝细胞癌治疗新进展

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DOI：10.12449/JCH250801

关键词：癌，肝细胞；肝切除术；分子靶向治疗；免疫疗法基金项目：国家自然科学基金（82273234）；上海市自然科学基金（21ZR1412200）

Thelatestadvancesinthetreatmentofhepatocellularcarcinoma

ZHOU Jian，HUANG Xiaoyong

DepartmentofeptoiaryurgerydLiersplantationoshnHospital，udnUesitygii

Corresponding author：ZHOU Jian，zhou.jian@zs-hospital.sh.cn （ORCID： 0000-0002-2118-1117）

Abstract：Hepatocelularcarcinoma（HCC）isaseverelydetrimental global public halth issue，anditsicidenceandmortality ratesremainatahighlevel.Acording tothedatafromthe WorldHealthOrganization，therewere866OoO newcasesofHCCand 759 000deaths worldwidein202，anditispredictedthatby2O40，there willbesignificantincreases inthenumbersofnewcases anddeathsduetoHCC.Inthefaceofthesegreatchallenges，significantadvanceshavebeenmadeinthediagnosisandtreatmentof HCC inecentyears，andfromtheimprovements intraditional surgeriesandlocaltreatmenttogroundbreaking inovationsin targeted therapyand immunotherapyandtheapplicationof theconceptof precision medicine，various treatment methods have providedmore treatmentoptionsandsurvivalopportunitiesforpatients withdiferentstages.Thisarticlereviewtheadvancs inthe treatmentofHCCandanalyzescurrenttherapeuticdificultiesandfuturedevelopmentdirections，nordertoprovideaeferencefor clinical practice and academic research.

Key Words： Carcinoma，Hepatocellular;Hepatectomy；Molecular Targeted Therapy； Immunotherapy

肝癌为世界上第六大常见癌症类型、癌症相关死亡的第三大原因，其中原发性肝癌常见的3种病理类型为肝细胞癌（HCC）肝内胆管癌（intrahepatic cholangiocarcinoma，ICC）和混合型肝细胞癌-胆管癌，其发病机制、治疗及预后有所不同。（剩余16314字）