肠道屏障功能障碍在肝肾综合征-急性肾损伤发病中的串扰机制

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Thecrosstalk mechanism of intestinal barrer dysfunction in the pathogenesis of hepatorenal syndrome-acute kidney injury

SUN Wen1'²，CHEN Xia I，2 ， ZHANG XinI，2 ，YUBorut ⋅I，2 ，YANG Bo ⋅1，2 ， XING Haitao I，2

1.DeparmentofphroloestAflatedHospialofanjinUniersityfditioalCineseMedicinen19， China;2.National ClinicalResearchCenterforChineseMedicineAcupunctureandMoxibustion，Tianjin30o193，China

Corresponding author： XING Haitao，haitxing@126.com （ORCID： 0009-0004-0382-7553）

Abstract：I2O15，theInternationalAscitesClubproposedanewdefinitionofhepatorenalsydrome-acutekidneyinjurybasedon theprogressonof hepatorenalsyndrome，andstudiesarestillbeingconductedtoexploretheexactpathogenesisofhepatorenal syndrome-acutekidneyinjury.Intestinalbarrerplaysanimportantbridgingroleinliver-kidneyconnection，andintestinaflora disturbance，bacterialtranslocation，andendotoxins enteringthebloodcausedamagetothekidneysbyreleasing proinflammatory cytokinesandactivatingimmune-relatedcels.Theentranceofbileacidintotheciulationsystemalsodirectlyorindirectlyleadto thedevelopmentandprogresionofhepatorenalsyndrome-acute kidneyinjury.Thisarticlereviewsthecrosstalkmechanismof hepatorealsydrome-acutekidneyijuryfromteperspectiveofteintestialbarierandfurterclarifiestekeyolofelivegut-kidney axis in the pathogenesis of this disease，in order to provide new treatment ideas.

KeyWords：Intestinal Barier;Liver Cirrhosis；Hepatorenal Syndrome；Acute Kidney Injury；Bacterial Translocation

Researchfunding：NationalNatural ScienceFoundationofChina（81973799）；Tianjin MunicipalEducation Commision Scientific ResearchProject（2023KJ154）

肝硬化是全球第11大常见死因，每年约导致200万人死亡[1]，在肝硬化失代偿期，患者可并发肝肾综合征（hepatorenalsyndrome，HRS）。（剩余21620字）