自身免疫性肝炎遗传机制研究进展

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基金项目:中国中医科学院科技创新工程重点项目(CI2021A00801)
Researchadvancesinthegeneticmechanismofautoimmunehepatitis
WANG Xinxian,CHEN Lanyu,LYU Wenliang
Departmentof Infectious Diseases,Guang'anmenHospital,ChinaAcademyofChineseMedical Sciences,BeijinglOoo53,China
Corresponding author: LYU Wenliang,lvwenliang@sohu.com(ORCID: 0000-0002-4552-919X)
Abstract:Autoimmunehepatitis(AIH)isachronic inflammatoryliverdiseasecausedbyimmuneabnormalities.Geneticfactors playanimportantroleinAIH.Theanalysisof genes hasshownthatnewgenetic markerscanhelptodepen theunderstandingof theriskof AIHand develop treatment measures.Thisarticlereviews theresearch advances in humanleukocyte antigen,single nucleotide polymorphism,and epigenetics,inorderto provideareference for clinicaltreatmentand research on AIH.
Key Words: Hepatitis,Autoimmune; HLA Antigens;; Single Nucleotide Polymorphism; Epigenomics
Research funding:Scienceand Technology InnovationProjectofChina AcademyofChinese Medical Sciences(CI2021A0801)
自身免疫性肝炎(AIH)是由免疫异常导致的慢性炎症性肝脏疾病,以血清自身抗体阳性、高免疫球蛋白GΩ⋅IgG )血症、氨基转移酶水平升高和病理组织学检查可见界面性肝炎为主要特征。(剩余16234字)