肝癌局部治疗策略

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关键词：肝肿瘤；肿瘤治疗方案；精准医学

Locoregionaltherapeuticstrategiesforhepatocellularcarcinoma

XIANG Hua la，2 ， LONG Lin²， ZHANG Yongjin²， ZHOU Jumei Ib ， ZHAO Yang ιa ，LI Muzt ;Ia ， LIU Rengeng²， SHI Shixiong²，WANG Rongrong2

1.a.Department of Interventional Vascular Surgery，b.Department of Abdominal Radiotherapy ，Hunan Cancer Hospital （The AffliatedTumorHospital，XiangySchoolofMedicine，CentralSouthUniversity），Changsha4o6，China；2.Departentof InterventionalndVascularurgeryHunanProncialeole'sospital（ThFistAfliatedHspitalofHunanNoalUiesity， Changsha 410000， China

Corresponding author： XIANG Hua， vipxiangh@163.com（ORCID： 0000-0001-7924-4670）

Abstract：Theincidenceandmortalityratesof hepatocellularcarcinoma（HCC）remainhigh in China，andtheapplicationof surgicalresectionisoftenlimitedduetotefacthatmostpatientsaeintheadancedstageattetimeofconfirmeddiagosis.This articlereviews commonlyusedadvancedlocoregional therapiesfor HCCandthe advances in mainstream techniques suchas local ablation（radiofrequencyablation，microwaveablation，reversibleelectroporationandcryoablation），intravasculariteetion （transcatheterarterialchemoembolization，hepaticarterialinfusionchemotherapy，andY9Ohepaticarterial infusion chemotherapy），andradiotherapy（CyberKnife，proton therapy，andheavy-iontherapy），andamultidimensionaldecision-making frameworkisconstructedforHCClocoregionaltherapybycomparing treatmentprinciples，indications，limitations，andclinical dataof these techniques.Thisarticleaimstoprovide evidence-basedsupportforpersistentdilemmasinclinical decision-making， promote theroleof locoregionaltherapiesinclinical practice，andproposethedirections forfutureresearchandclinical application.ThisarticlealsoestablishesacomprehensiveclinicalroadmapforHCClocoregionaltherapy，whichhelpstoaddress currentchallengesregarding techniqueselectionanddelineatefuturedirectionsforinnovation，inordertorshapethetreatmentof HCC through technological integration and paradigm innovation.

KeyWords：Liver Neoplasms；Antineoplastic Protocols；Precision Medicine

原发性肝癌在我国恶性肿瘤中发病率位居第4位，死亡率位居第2位[1]。（剩余20287字）