转运RNA衍生小RNA（tsRNA）的生物学功能及在肝脏疾病中的表达和临床意义

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基金项目：国家自然科学基金（81804142，82474570）；中国博士后科学基金面上项目（2023M731027）

Abstract：Liverdiseases cannot beeasilydetected in theearlystage，andalthough invasivediagnostic methods，suchas liver biopsy，arerelativelyaccuateteytendtoavealowdegreofacceptane，ichgreatlyliitstheimprovementindagnosisand treatmenttechiquesforliverdiseases.ThereforeitisofgreatimportancetosearchfornewiomarkersandtherapeuticagetsAsan emerging biomarkerforliquidbiopsy，tNA-derivedsmallRNA（tsNA）isbnomallexpressedinvarious liverdiseasesincluding viralhepatitisfattlveease，lveriuryndlraentvelodprogessflissby regulatingthebiologicalfunctionssuchasgeneexpresion，epigeneticregulation，andproteintranslation.Thisarticlereviewsthe origin，clasification，andbiologicalfunctionoftsRNA，aswellastheresearchadvancesintRNAasbiomarkersandpotential therapeutic targets forliverdiseases，soas to provideideas fortheearlydiagnosisand treatmentof liverdiseases.

KeyWords：MicroRNAs;LiverDiseases;Biomarkers

Research funding：National Natural ScienceFoundationof China（81804142，82474570）；ChinaPostdoctoralScienceFoundation General Program（2023M731027）

世界卫生组织报告显示，肝病相关死亡率存在显著地域差异：亚太地区肝病致死占比达 4.6% ，显著高于美洲 （2.7% 和欧洲地区（ 2.1% ）[1]。（剩余19018字）