液体活检在肝细胞癌诊断及治疗中的应用

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关键词：肝细胞癌；液体活组织检查；肿瘤细胞，循环；循环肿瘤DNA；细胞外囊泡基金项目：国家“十三五"科技重大专项（2018ZX10302204-001-003）

Abstract：Hepatocelularcarcinomaisoneof the mostcommoncancers，andduetothelackofobviousspecificsymptoms inits earlystage，patientsareoftenintheadvancedstageatthtimeofdiagnosisandtendtohaveapoorprognosis.Timelydiagnosisand ffective treatmentintheearlystagecanhelptoprolongthesurvivaltimeofpatients.Liquidbiopsyisanoninvasivetechniquethat canobtain theinformationof tumorbydetectingandanalyzingrelatedbiomarkers，including circulating tumorcels，circulating tumorDNA，andextracelularvesicles，therebycontributing toearlydiagnosis，molecularpathologicaltyping，andprognosis prediction.Thisarticlereviews theresearchadvancesin theaplicationofliquid biopsyinthediagnosisandtreatmentof hepatocellular carcinoma.

KeyWords：HepatocellularCarcinoma;；LiquidBopsy；eoplasticCels，irculating；CirculatingTumorDA;ExtracellarVesicles Research funding：National Scienceand Technology Major Projects of the 13th Five-Year Plan（2018ZX10302204-001-003）

原发性肝癌是癌症死亡的第二大常见原因[1]，其中肝细胞癌（HCC）是原发性肝癌的主要类型[2]。（剩余13412字）