《2025年亚太肝病学会临床实践指南:代谢相关脂肪性肝病的诊断和管理》摘译与解读

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基金项目:国家重点研发项目(2023YFA1800801);国家科技重大专项(2023ZD0508700);国家自然科学基金(82070588,82370577)
Excerptand interpretationof theAsianPacificAssociationfortheStudyof theLiverclinicalpracticeguidelines for the diagnosis and management of metabolic dysfunction-associated fatty liver disease in 2025
LEI Siyi 1,2 , LIAN Liyou I,2 , ZHENG Minghua1,2
1.DepartmentofInfectiousDiseases,TheFirstAfliatedHospitalofWenzhouMedical University,Wenzhou,Zhejiang35000 China;2.KeyLaboratoryofDiagnosisandTreatmentfortheDevelopmentofChronicLiverDiseaseinZhejiangProvince,Wenzhou, Zhejiang 325000,China
Corresponding author: ZHENG Minghua,zhengmh@wmu.edu.cn(ORCID: 0000-0003-4984-2631)
Abstract:SincetheAsia-PacificAssociationforthe Studyof theLiver(APASL)issuedtheclinical practiceguidelinesfor metabolicassociatedfattyliverdisease(MAFLD)in2O2O,theresearchonMAFLDhasbeenfurtherdeepened.Therefore,APASL has madecomprehensiveupdates andrevisions basedontheprevious guidelines,andthe latestversionof the clinical practice guidelinesfordiagnosisand managementof MAFLD,which wasreleased in February 2025,hasupdatedthe epidemiology, screning,asessent,and treatmentof MAFLD,aiming to promote theclinical practice,knowledge popularization,and scientificresearchofMAFLD.Thisarticlemakesan excerptandaninterpretationof theupdatedkeypointsoftheguidelines.
Key Words:Metabolic Dysfunction-AssciatedFattyLiver Disease;Diagnosis;Therapeutics;Practice Guideline
Research funding:National KeyR&DProgramofChina(2023YFA1800801);NationalScienceand TechnologyMajorProjec (2023ZD0508700); National Natural Science Foundation of China(82070588,82370577)
2020年亚太肝病学会(APASL)首先发布了代谢相关脂肪性肝病(MAFLD)的诊疗指南[1(以下简称"2020版指南”),但亚太地区肝病负担持续攀升,已成为全球肝病的主要原因,基于最新的研究证据,APASL在2020版指南的基础上进行了更新与修订,并于2025年2月在HepatologyInternational杂志上发布最新版MAFLD的诊断和管理临床实践指南[2(以下简称"2025版指南")。(剩余15213字)