原发性胆汁性胆管炎合并干燥综合征的免疫机制及靶向治疗研究进展

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Abstract：Primary biliarycholangitis（PBC）and Sjogren’ssyndrome（SS）are bothautoimmune disorders characterized by the involvementofepithelialtisse，andcomorbidityofPBCand SSisoftenobservedinclinicalpractice，suggesting thatthesetwo diseasesmayhavecommon pathogeneses.Currently，thereare stillnospecifictargeted therapies forPBCand SS，and the therapeuticapproach forsystemic manifestations mainlyrelieson the treatmentregimens forotherautoimmunedisorders.This articlereviewsthevarious potentialtherapeutictargets thathavebenclarifiedinthepathogenesisofPBCandSSandpointsout thattargeted therapies forthesetwodiseasescanbedevelopedbasedonthecommon immunopathologicalmechanismof PBCand SS，thereby providing valuable ideas for developing novel therapies.

Key words： Primary Biliary Cholangitis； Sjogren’s Syndrome; Immunomodulation； Molecular Targeted Therapy tesearch funding：Natural Science Foundation Project of Liaoning Province（2O23-MS-189

原发性胆汁性胆管炎（primarybiliarycholangitis，PBC）和干燥综合征（Sjogren'ssyndrome，SS）均在中老年女性中多见[1-2]，两者发病时均以疲劳、乏力和瘙痒症状常见。（剩余21218字）