基因修饰间充质干细胞在肝脏疾病治疗中的应用价值

打开文本图片集

基金项目：国家自然科学基金（82360132）；甘肃省卫生健康行业科技创新重大项目（GSWSZD2024-11）；甘肃省重点研发计划项目（22YF7FA085）；甘肃省联合科研基金项目（23JRRA1489，24JRRA911）；甘肃省中医药课题重点项目（GZKZ-2022-7）；甘肃省重点人才项目（甘组通字[2024]4号）

Abstract：Theimmunomodulatory，repair，andregeneration-promotingfunctionsofmesenchmalstemcelsmakethemoneofthe potentialtreatmentmethodsforliverdiseases.Atpresent，viralandnon-viraldeliverymethodshavebeendevelopedtogeneticaly modify mesenchyalstemcels，ndgenemodificationcanpromote thesurvival，oming，andcyokinesecretionofmesenchal stemcell，therebyenhancingtheabilityof mesenchymal stemcellstotreatliverdiseases.Thisarticlemainlysummarizes the researchadvancesingene-modifiedmesenchyalstemcelsinthetreatmentofliverdiseases，nordertoprovidenewinsightsand strategies for theclinical treatment of liver diseases.

Key Words：Mesenchymal Stem Cels;Organisms，Genetically Modified;Liver Disease;Therapeutics

Researchfunding：National NaturalScienceFoundationofChina（8236ol32）；MajorProjectofScienceandTechnologIovation in Health Sectorof Gansu Province（GSWSZD2024-11）；KeyR&DProgram ofGansu Province（22YF7FA085））;Joint Research FundProjectof GansuProvince（23JRRA1489，24JRRA911）；KeyProjectof Traditional Chinese Medicine in GansuProvince （GZKZ-2022-7）; Gansu Provincial Key Talent Project （Gan Group No.[2024]4）

肝损伤是由肝炎病毒、药物或毒物等引发的肝脏病理改变，其病程进展可导致肝硬化、肝衰竭及肝细胞癌（HCC）等终末期肝病。（剩余18263字）