胰岛素样生长因子-I（IGF-I）在肝硬化预后评估和治疗中的作用

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Abstract：Asakeymemberof theinsulin-likegrowthfactorfamily，nsulin-likegrowthfactor-I（IGF-I）ismainlysythsized intheliverandiswidelydistributedinthehumanbody，anditisivoledintephysiologicalproessssuchscellprolifation， diferentiation，metabolism，andapoptosis.StudieshaveshowtatthelevelofIGF-Iisnegativelycorelatedwiththeseverityof livercirrhosis，andIGF-Imainlyafectstheprogressionoflivercirrhosisbyinibiting liverfibrosis，promotingDNAdamage repair，andregulatinglipid metabolism.MonitoringofIGF-Ilevelisexpected toprovideanevaluationindicatorforimproving the prognosisof patientswith livercirhosis，and stimulatingtheactionpathwayofIGF-Iorregulatingitsexpresionlevelmay becomeanewmethodforthetreatmentoflivercirhosis.Thisarticlereviews theresearchadvancesinIGF-Iinlivercihosis，in ordertoprovide new ideasfor the diagnosisand treatment of liver cirrhosis.

Keywords：Liver Cirrhosis；Hepatic Fibrosis;Insulin-Like Growth Factor I;Prognosis

Research funding：Gansu Province Scienceand Technology Major Project Plan（23JRRA1487

肝硬化是一种由多种慢性肝病发展而来的严重病理状态，其特征是肝组织的弥漫性纤维化、假小叶形成及肝细胞的再生结节。（剩余19215字）