表观遗传学在瘦型非酒精性脂肪性肝病中的作用及临床应用前景

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关键词：非酒精性脂肪性肝病；表观基因组学；病理过程

基金项目：国家自然科学基金（81904154，82205086）；河南省科技攻关计划（242102310500）；河南省“双一流”创建学科中医学科学研究专项（HSRP-DFCTCM-2023-1-10）

Abstract：Epigeneticmechanismsplayacrucialroleinthedevelopmentandprogresionof nonalcoholicfaty liverdisease （NAFLD），especiallamong lean individuals.Theresearchonrelated epigenetic mechanismshasprovidednewcluesand direction forrevealing theunderlyingcausesandtreatmentstrategiesofNAFLD.Thisarticleintroduces theroleofepigeneticsin thedevelopmentandprogresioofNAFLDamongleanindividualsinrecentyears，analyzesthelatestresearchadvances inthe epigeneticsofNAFLDinthispopulation，and brieflydescribesthebasicconceptsofepigenetics，includingDNAmethylation， histonemodifications，andnon-codingRNAregulation.Thisarticlealsodiscusseshowepigeneticalterationsimpactthe pathogenesis，disease progression，and treatment strategies of NAFLD in lean individuals.

KeyWords：Non-alcoholic FattyLiver Disease；Epigenomics；Pathologic Processes

Researchfunding：NationalNatural ScienceFoundationof China（81904154，82205086）；ScienceandTechnology KeyProject of Henan Province（242102310500）；Special ResearchProjectfor Traditional Chinese Medicine Sciencein Henan Province's “Double First Class” Creation Discipline（HSRP-DFCTCM-2023-1-10）

非酒精性脂肪性肝病（NAFLD）包括非酒精性单纯性肝脂肪变、非酒精性脂肪性肝炎（NASH）肝硬化和肝细胞癌（HCC）[I]，是指排除酒精等明显造成肝损伤的因素之外的一种多系统代谢性疾病[2]。（剩余16491字）