中药调控肿瘤相关巨噬细胞对肝细胞癌的治疗作用与机制
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基金项目：陕西省中医药管理局中医药科研项目（SZY-KJCYC-2025-JC-004）；秦创原中医药产业创新聚集区项目（L2024-QCY-ZYYJQ-Y09）；咸阳市中青年科技领军人才项目（L2022CXNLRC018）；咸阳市科学技术局重点研发项目（2021ZDYF-SF-0037）
Abstract：Livercancerhasighprevalenceandmortalityratesaroudtheworld，nditsdevelopmentandprogressionareclosely associatedwiththeinteractionbetweenthetumormicroenvironentandtumo-asociatedmacropages（AMs）.TAMsplyasignificant roleinimmunesuprsionimmunesape，cellproliferation，invasion，metastasis，anddugresistaceinlivercanceradiioal Chinesemedicine（TCM），withitsunique therapeuticconceptsandmethods，has showngreatpotentialinregulating TAMsand improvingtheprognosisoflivercancer.Thisarticlereviews theroleand molecular mechanismsof TCMinregulating TAMsforthe treatmentflvecacer，susssteyoleofAsineprogresiooflercancerndanalystepactofeseicinal componentsontherecruitment，polarization，andactivityofTAMsandtheexpresionofrelatedfactorsbasedoTCMtheoryStudies haveshownthatTCMcanregulatetheplarizationstateofTAMs，promoteteformationofM-typeatitumormacropages，ndiibit theactivityofM2-typetumormacrophages，therebyplayingaroleininhibitingtheproliferationoflivercancercels，promoting apoptosis，inbitingagiogenesis，andehancingimmuneresponse.Inaddition，tisarticlealsosummaresthemoleularargetnd mechanisms ofactionof TCMmonomers，compound prescriptions，andnovel preparations inthe treatmentof livercancer，suchas inhibitigthesecretionofcyokinesbyTAMs，regulatingsignalingpathways，andectingmetabolicpathways，inordertoprovidea scientific basis fortheapplicationofTCMinlivercancertreatmentandofernewideas forimmunotherapyforlivercancer.
Key Words：Liver Neoplasms；Tumor-Associated Macrophages；Traditional Chinese Drugs
Research funding：TraditionalChinese Medicine ScientificResearchProjectofShanxiProvincialAdministrationofTraditional Chinese Medicine（SZY-KJCYC-2O25-JC-004）；QinChuangyuan Traditional ChineseMedicineIndustryInnovationAggregation ZoneProject（L2024-QCY-ZYYJJQ-Y09）；YoungandMiddle-aged Scientificand TechnologicalLeading TalentsProjectof Xianyang City（L2022CXNLRC018）；KeyR&DProjectof Xianyang Science andTechnology Bureau（2021ZDYF-SF-0037）
肝细胞癌（HCC）作为全球性高发病率、高病死率的疾病，其发病机制涉及病毒性肝炎、长期饮酒、非酒精性脂肪性肝病等多个因素[1]。（剩余21970字）