新技术在慢加急性肝衰竭全病程管理中的转化与落地

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通信作者：，haili_17@126.com（ORCID：0000-0003-4174-9758）

Translation and implementation of new technologies in the whole-course management of acute-on-chronic liver failure

HEKai，LIHai

DepartmentofGastroenterology，hanghaiIstituteofDigestiveDisease，RenjiHospitalhanghi JiaoTongUniversityhoolo Medicine，Shanghai200001，China

Correspondingauthor：LI Hai，haili_17@126.com（ORCID：0000-0003-4174-9758）

Abstract：Acute-on-chronicliverfailue（ACLF）isaformofacutehepaticinsuficiencythatoccursinthecontextofachronic liverdisease，witharelativelyhighmortalityrate.ToimprovetheprognosisofACLFpatints，itissentialtoarlyidentifythe patients withpre-ACLFandconstantlyoptimizeandinovatetreatmentregimensforthediseaseintheprogresivestage.Wih more than10yearsofresearch，the Chinese CLIFconsortiumhasdevelopedanearlywarning modelforACLFand establishedasystem fortransferinghigh-riskpatients totertiaryhospitals.Atpresent，thereal-worldstudyhasalsoconfimedtheconsistencybetwen theearlywarningmodelandactualconditions inclinical practice，makingcontributions totheearlysreening，diagnosis，and treatmentofACLF.ThetreatmentoptionsfortheprogressivestageofACLFarealsoexpanding，fromthedevelopmentofiovative pharmaceuticalstotheuseofartificialliversupportandstemcelltherapy，andsuchtreatment modalities have madesignificant achievementsinclinicalstudiesandareexpectedtobeimplementedinthenearfuture.Thedevelopmentofamoreeicient diagnosticsystemandnovel treatmentmodalitieshasled toasignificantimprovementinthediagnosisandtreatmentofCLF.

KeyWords：Acute-On-Chronic Liver Failure；Early Diagnosis；Therapeutics；Prognosis

1慢加急性肝衰竭（ACLF）全病程的两阶段特征

ACLF作为肝衰竭中的主要类型，具有短期病死率高和病情发展迅猛的特点[1]。（剩余12233字）