慢加急性肝衰竭预后评分模型和标志物研究进展
打开文本图片集
Research advances in prognostic score models and biomarkers for acute-on-chronic liver failure
XU Xinyi，YU Xia，TUHuilan，QIAN Xiaohan，YANGYida，SHI Yu
StateKeyLboatorfogosisndTrmentffectioeas，estfatedHospitalejngUesityoolof
Medicine.Hangzhou310003，China
Corresponding author： SHI Yu， zjushiyu@zju.edu.cn （ORCID： 0000-0002-9392-7176）
Abstract：Acute-on-chronic liverfailure（ACLF）isacomplexclinicalsyndrome，andearlyidentificationandaccurateprognostic evaluationareof greatimportanceforpatienttreatmentandmanagement.Inrecentyears，within-depth researchonthe pathogenesisofACLF，multipleprognosticbiomarkershaveeenproposedandusediclinicalpractice.Thisarticlesysteatialy reviews theresearchadvances inprognosticbiomarkersforACLFfromtheaspectsof clinical predictive models，immunological biomarkers，metabolic biomarkers，geneticandepigenetic biomarkers，microbiome-related biomarkers，andemerging technologies suchasartificialintellgenceandulti-omics，nditalsodiscusestevalueandapplicationprospectsoftesebiomarkesthe prognostic evaluationofACLFandproposesfutureresearchdirections，norder toprovideasientificandcomprehensivereferencefor clinicians，guide individualizedtreatmentandmanagementofACLFpatients，ndfinallimprovetheclinicaloutcomesofatients.
Key Words：Acute-On-Chronic Liver Failure;Prognosis；Biomarkers；Models，Statistical
Research funding： National Key Research and Development Program of China （2O22YFC2304500）
慢加急性肝衰竭（ACLF）是一种慢性肝病急性加重引起的危重症，常伴发多器官功能障碍，其病死率极高。（剩余21970字）