机器人胰腺实质保留手术与腹腔镜胰腺实质保留手术治疗胰腺神经内分泌肿瘤的效果比较

打开文本图片集

Abstract：ObjetiveTcompareandanalyetheclinicalappicationofrobot-asistedparechymal-sparingpancreatectomy（R-PSP） andlaparoscopicparenchymal-sparingpancreatectomy（L-PSP）inthe reatmentofpancreaticneuroendocinenoplasm（pNE）and to evaluatethesafetyandefcacyof theR-PSPprocedure.MethodsAretrospectiveanalysiswasperfoedfortheclinicaldataofpEN patientswhoundewentparencalsparingpancreatectomyinDepatmentofGeneralSrgery，eking UnionMedicalColeHospial， Peking Union MedicalColege，ChineseAcademyofMedicalSciences，fromDecember2017toAugust2023，andaccording tothe minimallyinvasivesurgicalprocedure，theyweredividedintoR-PSPgroupandL-PSPgroup.R-PSPandL-SPwerecomparedintesof theeffcacyofminimallyinvasiveprocedure，theoutcomeofpostoperativecomplications，andoncologicalficacyTheindepedentsamples t test or the Mann-Whitney U test was used for comparison of continuous data between two groups ; the chi-square test or the Fisher's exact test was used for comparison of categorical data between two groups；the Mann-Whitney U test was used for comparison of ranked data betweentwogroups.RsultsAtotalof45pNENpatientswereincluded，with9intheR-PSPgroupand36intheL-PSPgroup，andtere were no significant differences in baseline data between the two groups（all P>0.05 ）.There were no significant differences between the twogroupsinefationtropativbloodloss，traopativebodassiondteateofoesiotoaoto （all P>0.05 ）.Compared with the L-PSP group，the R-PSP group hada significantly longer length of postoperative hospital stay [10.00（9.00—15.00） days vs 7.50（ 6.00-10.00） days， Z=-2.356 ，P=0.017]and significantly higher hospital costs [86 610.44 （81 905.39—114 401.24） yuan vs 38 781.20 （31 708.39—50 514.76） yuan， Z=-4.001， P<0.001 ].There were no significant differences between the two groups in the incidence rates of serious postoperative complications（Clavien-Dindo grade ⩾II ），clinically relevant pancreatic fistula，delayed gastric emptying，and intra-abdominal infection（all P>0.05 ）. The postoperative 90-day mortality rate was 0% for both groups.ConclusionR-PSP has acceptable safety and efcacyin pNEN patients in clinical practice.

Key Words： Pancreatic Neuroendocrine Neoplasm；Robotic Surgical Procedures； Laparoscopy；Treatment Outcome

Researchfunding：NationalNaturalScienceFoundationofChina（82272917）；National HighLevelHospitalClinical Research Funding（2022-PUMCH-B-004）

胰腺神经内分泌肿瘤（pancreatic neuroendocrine neoplasm，pNEN）是一类起源于肽能神经元和神经内分泌细胞的罕见肿瘤，在分化程度、生物学行为上具有高度异质性。（剩余11426字）