关于药用辅料苯扎氯铵含量测定方法的探讨

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Abstract：Bycomparing three methods forthecontent determinationofbenzalkoniumchlorideandanalyzing theadvantages anddisadvantagesofeachmethod，themostconvenientandfeasiblemethodforthecontentdeterminationofbenzalkonium chloridewasiscused，soastoprovidereferencefortheualitycontrolandstandardsdevelopmentofbenzalkoumchloride usedasapharmaceticalexcipientTeighperfomancelquidhomatogaphy（HLC）otassmoateitratiodo tetraphenylborate trationmethods wereusedtodeterminethecontentofbenzalkoniumchloride.Thepotasiumiodatetitration andsodium tetraphenylborate titrationmethods werecalculatedbasedonfixedandmodifiedtitrationdegree，andtheresults were compared.Comparedwithchemicaltitrationmethods，thecontentsofsamplesdeterminedbyHPLCwere higherindifferent degrees.Nosignificantdifferencewas foundfromthecontentresultsofsamplesbetweenthesodium tetraphenylboratetitration methodandteotasdatetratoeodutthrallsfstsotdtabateiaiot was much better than the potassiumiodate titration method，the alignment deviationofwhich was less than 1% .Comparedwith the calculationresultsbasedonfixedtitrationdegree，theresultscalculatedbasedonmodifedtitrationdgreecouldreflecttheactual contentmoreaccurately.Amongthethremethods，theresultsofHPLCwerehgherthanthoseofchemicaltitration，andsodium tetraphenylboride titration was preferred to calculate thecontent basedon the modifiedtitration degree.

Keywords：benzalkonumchloride;contentdetermination;highperformanceliquidchromatography;potassumiodatetitration; sodium tetraphenylborate titration

0 引言

苯扎氯铵又名洁尔灭（Benzalkoniumchloride，简称BAC），是一种具有杀菌作用的季铵盐类阳离子表面活性剂，属于低效消毒剂，通过改变细胞膜通透性使菌体物质渗出，进而阻碍细菌代谢使其死亡[1]。（剩余4721字）