褪黑素及脂肪干细胞移植修复脊髓损伤的研究进展

Research Progress of Melatoninand Adipose Derived Stem Cells Transplantation for Spinal Cord Injury/TAN Weiyuan，ZHANG Wei，LI Qing，MA Tianyong.//Medical Innovation of China，2025，22（17）： 183-188

[Abstract]Spinalcord injury is aserious traumatic disease in spinal surgery，and its occurrence mechanism is acomplex pathological process.At present，the treatment methods for spinal cord injury mainly include surgical treatment and non-surgical treatment.Surgical treatment includes anterior surgery，posterior surgeryand combined anterior surgery，and non-surgical treatment mainly includes drug therapy，hyperbaric oxygen therapy， etc.Melatonin，as a neurohormone，may promote the repair of spinal cord injury through mechanisms such as antioxidation，reducing inflammatory response，maintaining the integrityof the blood-spinal cord barrier，and maintaining microcirculation.Adipose derived stemcelsalso havearepairing efectonspinal cord injury，which maybe related to its mechanisms such as reducing inflammatory response and promoting angiogenesis.Melatonin and adipose derived stemcells transplantation are expected to become new efective treatment methods for spinal cord injury.Pretreatment，improvementof the transplantation environment and combined therapy can enhance the therapeutic effect of adipose derived stemcells transplantation.

[Key words] Spinal cord injury MelatoninAdipose derived stem cells

First-author'saddress：Department of Orthopedics I，the Fifth Affiliated Hospital of Zunyi Medical University，Zhuhai，Zhuhai5191oo，China

doi：10.3969/j.issn.1674-4985.2025.17.042

脊髓损伤（spinalcord injury，SCI）是脊柱外科严重创伤性疾病[1]，其致伤原因主要为高处坠落、车祸、压砸伤等高能量损伤[。（剩余15452字）