消旋卡多曲颗粒在轮状病毒性肠炎患儿中的疗效及对肠黏膜屏障指标的影响

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TherapeuticEect of Racecadotril Granules in Children with Rotavirus Enteritisand Its Influence onIntestinal Mucosal Barrier Indicators/SUNYusheng，TANGRongning，CHENXiangjian.//Medical Innovation of China，2025，22（17）： 039-043

[Abstract] Objective：To investigate the therapeutic effect of Racecadotril Granules in children with rotavirus enteritisand its influenceon intestinal mucosal barrierindicators.Method：A totalof1OOchildren with rotavirus enteritis admitted to Ningde Municipal Hospital ofNingde Normal Universityfrom January 2O22 to January 2024 were divided into two groups according to the random number table method，with 5O cases in each group.The control group received conventional treatment，and the observation group was treated with Racecadotril Granules on the basis of the control group.The total effective rate，incidence of adverse reactions，disappearance time of symptoms，serum and fecal inflammatory factors [interleukin-8 （IL-8） and interferon- γ （IFN |-γ| ）] and intestinal mucosal barrier indicators [diamine oxidase （DAO）， D-lactic acid （D-Lac） and endotoxin （ET）] were compared between the two groups.Result：The total effective rateof the observation group was significantly higher than thatof the control group，and the disappearance time of symptoms in the observation group were significantly earlier than those in the control group，the differences were statistically significant （ P <0.05）. There was no statistically significant difference in the incidence of adverse reactions between the two groups （ Pγ 0.05）.Before treatment， there were no statisticallysignificantdiffrences inserumandfecal inflammatoryfactorsand intestinal mucosal barrierindicators between the two groups （ P>0.05 ）.After 3 and 6 days of treatment， the serum and fecal inflammatory factors and intestinal mucosal barrier inboth groups were significantly lower than those before treatment，and the serum and fecalinflammatory factorsand intestinal mucosal barier intheobservation groupwere significantlylower thanthose in the control group，the diferences were statistically significant （P

[Keywords] Racecadotril GranulesRotavirus enteritisIntestinal mucosal barrier

First-author's address：Department of Pediatric，Ningde Municipal Hospital of Ningde Normal Jniversity，Ningde352100，China

doi：10.3969/j.issn.1674-4985.2025.17.009

轮状病毒性肠炎为轮状病毒感染所致的消化道疾病，发病人群以婴幼儿为主，对患儿的危害较大。（剩余5878字）