曲美他嗪联合肺泡灌洗对重症肺炎患者肺功能及免疫功能的影响

打开文本图片集

Impact of Trimetazidine Combined with Alveolar Lavage on Pulmonary Functionand Immune Function inPatientswith SeverePneumonia/LIU Zijun，HUA Yuyu.//Medical InnovationofChina，2025， 22（17）： 019-023

[Abstract]Objective：To explore the efects of Trimetazidine combined with alveolar lavage on the pulmonary function and immune function of patients with severe pneumonia.Method： A total of 9O patients with severe pneumoniaadmited toLeping People's Hospitalfrom May 2O22 to May 2O24 were selectedand divided into two groups according tothecomputer grouping method，with45cases ineach group.Thecontrol groupwasgiven alveolar lavage treatment，whilethe observation group was treated with Trimetazidineon thebasis of the control group.The pulmonary infection，cell activity indicators，pulmonary function，immune function and the occurrenceof adverse events in the two groups were observed.Result： After the treatment，the clinical pulmonary infection score （CPIS），myeloperoxidase （MPO），matrix metalloproteinase2 （MMP-2）， matrix metalloproteinase9 （MMP-9），and CD8 + in the observation group were all lower than those in the control group，the levels of peak expiratory flow（PEF）， forced expiratory volume in one second （ FEV1， ），forced vital capacity（FVC），FEV1/FVC，CD 3+ ，CD 4+ ，and CD4+/CD8+ were all higher than those in the control group，the differences were statistically significant （ P <0.05）. There was no statistically significant difference in the incidence of adverse events between the two groups （ P>0.05 ）.Conclusion： The application of Trimetazidine combined with alveolar lavage in patients with severe pneumonia can notonly control pulmonary infection，reduce inflammatory response，butalso improve pulmonary function，enhance immune function， and has relatively high safety.

[Key Words] Severe pneumonia Alveolar lavageTrimetazidinePulmonary function

First-author'saddress：Departmentof Respiratory and Critical Care Medicine，LepingPeople's ospital，eping33330o，China

doi：10.3969/j.issn.1674-4985.2025.17.005

重症肺炎是由肺炎链球菌、支原体、病毒等感染引起的，主要临床症状有高热、咳嗽、呼吸功能障碍等[1-2]。（剩余5857字）