基于肠道菌群及代谢产物探究针灸治疗2型糖尿病胰岛素抵抗的作用机制

[关键词]2型糖尿病；胰岛素抵抗；针灸；肠道菌群；胆汁酸；短链脂肪酸；炎症反应 [中图分类号]R246 [文献标志码]A [文章编号]doi：10.3969/j.issn.1674-070X.2025.08.030

Mechanism of action of acupuncture and moxibustion in treating insulin resistance in type 2 diabetes mellitus based on intestinal microbiota and its metabolites

ZHAO Yue， ZUO Jun*， YU Zining， NIE Longze Heilongjiang University of Chinese Medicine， Harbin， Heilongjiang 15oo4o， China

[Abstract]Theintestinal microbiotaiscloselyasociatedwiththepathogenesisof type2diabetesmelitus （2D），inwich abnormalbileacidBA）andsorhanfattacidSCF）metabolsmaswellasiamatoresponssareallinvoldAcuucture and moxibustionmayregulateBAmetabolism toenhance theexpressionoftakeda Gprotein-coupledreceptor5（TGR5）and glucagon-likepeptide-1（GLP-1）；modulateSCFAmetabolismtoincreaseitstotalamountandaleviateinflammation;andegulate inflammatoryresponsestoinibitrelevantsignalingpathways.Basedonintestinalmicrobiotaanditsmetabolites，thispaperdelves intothemechanismofactionbywhichacupunctureandmoxibustiontreatinsulinresistance（IR）inT2DM，aimingtoprovidenew directions for T2DM treatment.

[Keywords]type2diabetesmelitus；insulinresistance;acupunctureandmoxibustion;intestinal microbiota;bileacid; short-chain fatty acid;inflammatory response

2型糖尿病（type 2diabetesmellitus，T2DM）是以慢性高血糖为主要特征的代谢性疾病，发病机制复杂。（剩余13543字）