基于“气火失衡”理论探讨甲状腺结节“结癌转化”防治

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[中图分类号]R273

[文献标志码]A [文章编号]doi：10.3969/j.issn.1674-070X.2025.08.017

Prevention and treatment of "malignant transformation" of thyroid nodules based on the theory of "qi-fire imbalance"

LIU Guangnuo'，WANG Zhengang²*， LAN Jinxiu'， LIANG Cui’， LIU Shijuan' 1. Graduate School of Guangxi University of Chinese Medicine， Nanning， Guangxi 53ooo， China; 2.TheFirst Hospital ofGuangxi UniversityofChinese Medicine，Nanning，Guangxi53oooo，China

[Abstract]Thyroid noduleisa commonendocrine disease.Dueto delayed detection orinsuffcientatention，many patientsexpernceprolongeddiseaseprgresion，witsomoduleseventuallytransforingintoancer.Teprocessof"aliant transformationofthyroidnodules”isdynamic.BasedontheChinesemedicine（CM）theoryof"qi-fireimbalance"，thispaper systematicallyelucidatedthepathologicalmechanismsandpreventionandtreatmentstrategiesforthetransformationofthyroid nodulesintocancer.Spleen-stomachweaknessisthecentral link leading tothedynamicimbalance betwenyuan-primordial qideficiencyandexcessveyinfire，whichinitiatesapathologicalcascadeof"defiiencystagnation，plegm，fireandtoxin"， therebyremodelingthenodulemicroenvironment.Specificall，thedysfunctionofspleenandstomachtransportionand transformationresultsinintertwinedphlegmandbloodstasis，whileexcessiveyinfirepromotesthetransformationof phlegm andstasisintotoxins，ultimatelyformingthepathologicalbasisforcancerthrough "toxindamagingthecolaterals".Following theprincipleof preventingadisease beforeitarises，athree-stagestrategywasproposed：intheearlystage，strengtheningthe spleenandbenefitingqitostrengthenthebodyandnourishtheorigin;inthemiddlestage，regulatingqiandreducingfireto resolvephlegmandstasis;andinthelatestage，detoxifyingandsupportingthehealthyqitotransfomstasisandunblock colaterals.ThisaproachaimstoprovideatheoreticalandpracticalCMpathwayforpreventingmalignant transformationof thyroidnodules，highlightingtheuniqueadvantagesofCMinallviatingsymptom，regulatingmicroenvironment，andeversing pathological progression.

[Keywords]thyroidnodules；qi-fireimbalance；malignanttransformation;preventionand treatment；malignanttransformation of thyroid nodules;preventinga disease before it arises

甲状腺结节是甲状腺滤泡上皮细胞及间质局灶性生长引起的散在病变，其中恶性结节占比 8% 216%[1-2] 。（剩余10875字）