从“脾为之卫”理论探讨肠道菌群在代谢性炎症中的作用

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[中图分类号]R228 [文献标志码]A [文章编号]doi：10.3969/j.issn.1674-070X.2025.08.018

[Abstract]Metabolicinflammation，achroniclow-gradeinflammatorystate，maydisruptinternalhomeostasisandenergy metabolismbalance，therebytriggeringmetabolicdisorders.Thegutmicrobiotaplaysacriticalroleinregulatinghostenergy metabolismandimmuneresponses，andmodulationofthegutmicrobiotacanefectivelymitigatetheprogressionofmetabolic inflammationAccordingtoChinesemedicine（CM）theory，thespleenisregardedasthefoundationofacquiredconstitutionfrom whichthetheoryof"thespleenactingastheguardofthebody"isderived.Thistheoryprofoundlyreflectsthespleen'sdual functions：regulatingenergymetabolismthroughthetransformationandtransportationofwater，foodandfluids，anddefending againstexteralpathogensbyparticipating inimmuneregulation.Thistheoryexhibitsasignificantcorelationwiththergulatory mechanismsof gutmicrobiota inmodernmedicine.Spleenqi deficiencyleads toanimpaireddefensivefunctionofthe spleen， disruptingmetabolicregulationandimmunebalanceinthebody.Thisresultsintheabnormalreleaseof inflammatoryfactorsnd ultimatelytrigersmetabolicinflammation.Tisifammatoryprocssisslowandpersistentanditslongprogesoay contributetothedevelopmentofvariousmetabolicdiseases，suchasdiabetesmelitus.Intreatingmetabolicinflammation，CM emphasizes the principleof addressingboth therotcauseandsymptoms，focusingonstrengthening the spleenandtonifyingqito strengthenthebody，whiletransformingturbidityandresolvingphlegmtoaleviatesymptoms.Ifthespleen’sguarding function remainscompromisedoveranextendedperiod，pathologicalproductssuchasphlegmturbidityandbloodstasiscanaccumulate， necesitatingtreatmentstrategiesthatnourishyinandemovetoxins.Furtherin-depthexplorationoftheinteractionmechanisms betweenthetheoryof"thespleenactingastheguardofthebody"andthegutmicrobiotainthedevelopmentandprogressionof metabolic inflammationwillprovide importanttheoretical guidanceand practical insights from CMforclinical treatment.

[Keywords]metabolicinflammation；thespleenactingastheguardofthebody；intestinal microbiota;metabolicdisorders;immune regulation

代谢性炎症是机体内巨噬细胞等免疫细胞在代谢紊乱的情况下，由游离脂肪酸、脂多糖（lipopolysac-charide，LPS）等代谢产物诱导的一种慢性低度性炎症。（剩余19437字）