柴芍承气汤联合低分子肝素治疗高脂血症性急性胰腺炎腑实热结证临床研究

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[中图分类号] 18657.5+1 [文献标志码］A [文章编号]0256-7415（2025）20-0051-07

DOI:10.13457/j.cnki.jncm.2025.20.010

Clinical Study on Chaishao Chengqi Decoction Combined with Low Molecular Weight Heparin for Hypertriglyceridemia-lnduced Acute Pancreatitis with Fu-Organ ExcessHeat Accumulation Syndrome

BIAN Yinyan，XU Yanfang，LIU Xianyong

DepartmentofGastroenterology，HangzhouLin'anTraditionalChinese Medicine Hospital，Hangzhou Zhejiang 3113Oo,China

Abstract：Objective：To observe the clinical effcacy of Chaishao Chengqi Decoction combined with low molecular weight heparin（LMWH）in treating hypertriglyceridemia-induced acute pancreatitis （HLAP）with fu-organ excess-heat accumulation syndrome.Methods:A total of 82 HLAP patients with fu-organ excess-heataccumulation syndromeadmited to Hangzhou Lin'an Traditional Chinese Medicine Hospital from January 2O23 to December 2024 were divided into the trial group and the control group using therandom number table method，with 41 cases in each group.Both groups received conventional treatment，with thecontrol group aditionallreceiving LMWHand the trial groupreceiving both LMWHand Chaishao Chengqi Decoction for seven days.Clinical eficacy，gastrointestinal function recovery time between the two groups were compared，traditional Chinese medicine syndrome scores，inflammatory factors，blood lipid indexes，pancreatic indexes，and intestinal barier function markers before and after treatment between the two groups were compared.Results：After seven days of treatment，the total efectiverate in the trial group was 92.50%(37/40），which was higher than the control group's 76.32% (29/38） ( P-6 ），triglycerides（TG），lipase（LPS），amylase（AMY），D-lactate（D-LA），diamine oxidase （DAO），soluble advanced glycation end product receptor（sRAGE），and endotoxin（ET）in both groups decreased compared to before treatment ( P

Keywords:Hypertriglyceridemia-induced acute pancreatitis；Fu-organ excess-heat accumulation syndrome; Chaishao Chengqi Decoction；Low molecular weight heparin；Triglycerides；Inflammatory factors； Intestinal barrier function

急性胰腺炎（AP）是因多种因素致胰酶提前激活而引起胰腺组织自身消化、出血、水肿甚至坏死的一种急腹症，临床以腹痛、腹胀、发热及恶心呕吐等为主要表现。（剩余14712字）