厚朴排气合剂联合常规疗法治疗颈髓损伤后神经源性肠道功能障碍临床研究

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[关键词］颈髓损伤；神经源性肠道功能障碍；厚朴排气合剂；炎症因子；机械通气；中医证候积分 [中图分类号]R274.9；R651.2［文献标志码］A [文章编号]0256-7415（2025）01-0066-06 DOI:10.13457/j.cnki.jncm.2025.01.014

Clinical Study on Houpo Paiqi Mixture Combined with Conventional Therapy for Neurogenic Bowel Dysfunction After Cervical Spinal Cord Injury

SONG Qingfeng，WANG Fengying，YANG Xiaojing

IntensiveCare Unit，LuoyangOrthopedic-Traumatological HospitalofHenanProvince/HenanProvincialOrthopedic Hospital，Luoyan Henan，China

Abstract:Objective：To observe thecurative efect of Houpo Paiqi Mixture combined with conventional therapy on earlyneurogenic bowel dysfunction（NBD）aftercervical spinal cord injury（CSCI).Methods:A total of 90 cases of patients with NBD afterCSCI admited to Luoyang Orthopedic-Traumatological Hospital of Henan Province from December 2O21to December 2O23 were selectedand divided intothetreatment group and thecontrol group according to the random number table method，with 45 cases in each group.Both groups were given lifesupportand conventional modern medical treatment，and the treatment group wasadditionally treated with Houpo Paiqi Mixture.Clinical ffects werecompared between the two groups；the changes in traditional Chinese medicine syndrome scores，abdominal distension scores，NBD scores，white blood cellcount （WBC），C-reactive protein（CRP），procalcitonin（PCT）， and Acute Physiologyand Chronic Health Evaluation II（APACHE II）scores before and after treatment were compared between the two groups；the mechanical ventilationrates during treatment and average durationof mechanical ventilation withinone week werecompared between the two groups.Results:The total efectiverateof clinical ffect was 97.8 % （44/45）in the treatment group and 71.1% (32/45）in the control group，with a significant difference ( P

Keywords：Cervical spinal cord injury；Neurogenic bowel dysfunction；Houpu Paiqi Mixture；Inflammatory factors；Mechanical ventilation；Traditional Chinese medicine syndrome scores

脊髓损伤后可导致神经、体液调节受损，继而导致一系列消化道功能障碍，如结肠张力下降、胃排空异常、结肠蠕动异常、排便障碍等，临床表现为腹胀、便秘、腹泻等症状，称为神经源性肠道功能障碍(NBD）。（剩余10927字）