强力枇杷露联合布地奈德福莫特罗吸人粉雾剂治疗咳嗽变异性哮喘临床研究

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[中图分类号］R562.2 [文献标志码］A [文章编号]0256-7415（2025）01-0061-05

DOI:10.13457/j.cnki.jncm.2025.01.013

Clinical Study on Qiangli Pipa Syrup Combined with Budesonide Formoterol Inhalation in Treating Cough Variant Asthma

PAN Yinchi,GU Jinghua, XU Xudong Department of Respiratory Medicine，Putuo DistrictPeople'sHospitalof Zhoushan，Zhoushan Zhejiang 3161o,China Abstract:Objective：To observe the clinical effctof Qiangli Pipa Syrup combined with Budesonide Formoterol

Inhalation in the treatment of cough variant asthma(CVA).Methods:A total of 96 patients with CVAadmitted to

Putuo District People's Hospital of Zhoushan from January 2022 to January 2024 were selectedand randomly divided

into the western medicine group and the combination group，with 48 patients in each group.The western medicine group

was treated with Budesonide Formoterol Inhalation，and the combination groupwas treated with oral administrationof

Qiangli Pipa Syrupbased onthe treatment ofthe western medicine group.Both groups were treated for fourconsecutive

weeks.Clinical efects were evaluated inthe two groups.The changes in the cough symptom scores，lung function

[forced expiratory volume in one second ( FEV1 ），forced vital capacity（FVC）， and peak expiratory flow

percentage (PEFpred%)]，and the levels of inflammatory indicators [eosinophil percentage ( E0S% ）and immunoglobulin E（IgE)]were compared between the two groups before and after treatment.The incidence of adverse reactions was counted.Results: The total effective rate in the combination group was 97.92% （47/48），which was higher than that in the western medicine group at 85.42% (41/48） （ P1 ，FVC，and PEFpred % in the two groups were increased when compared with those before treatment（ P1 ，FVC，and PEFpred% in the combination group were higher than those in the western medicine group ( P0.05 ).Conclusion: The combination of Qiangli Pipa Syrupand Budesonide Formoterol Inhalation is effective intreating CVA，which can improve patients'lung function and alleviate respiratory inflammation，with few adverse reactions and high safety.

Keywords：Cough variant asthma；Qiangli Pipa Syrup；Budesonide Formoterol Inhalation；Cough symptom scores；Lung function；Inflammatory factors

咳嗽变异性哮喘(CVA)是一种以慢性咳嗽为临床症状的特殊类型哮喘，主要表现为剧烈干咳，夜间或天冷尤甚，若治疗不当，易诱发典型哮喘，严重影响患者生活质量。（剩余9331字）