多b值DWI影像组学特征稳定性、可重复性及其对肝硬化的诊断效能

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[Abstract]Objective：Toevaluatethestabilityrepeatabilityanddiagnosticvalueofmulti-b-valueDWIradiomicsfeatures inlivercirrhosis.Methods：DWIdatasetswithmulti-b-valueof126cirhosispatientsinthelivercirhosisgroupand 102healthyvoluntersinthecontrolgroupwerecolected.Then，9OradiomicsfeatureswereextractedfromDWIimages.The variation was evaluated by the percentage coefficient of variation （ % COV），and the concordance correlation coefficient （CCC） wasappliedtoassesstherepeatabilityofDWIimages.Thefeatureswiththelowvariabilityandhighrepeatabiltyacross dferentb-valuesandpatientswereobtained.Another53livercirhosispatientsand53healthycontrolswerecollectedasthe externalvalidationcohortforevaluatethediagnosticeficiencyofradiomicsfeaturesforlivercirhosis.ROCcurveswereused toevaluatethediagnosticeficiencyofradiomicsfeaturesforlivercirrhosis.Results：Twenty-sixradiomicfeatureshadlow variation （ % COv < 20 % ）with multi-b-value and different patients.Thirteen features，such as GLRLM-RLNUN，GLCM-J.Entropy， between the liver cirrhosis group and the control group were statistically significantly different（all P<0.05 ）.The radiomics featureswithhigherrepeatabilitywereextractedfromDWIimagewithneighborbvalues.Intheexternalvalidationcohort， GLRLM-RLNUN，GLDM-DNUN，GLCM-J.EntropyGLCM-SumEntropy，IH-EntropyhadtheAUCsof0.924，0.967，0.865，0.891， andO.887，respectively.Conclusions：Therearevaryingdegreesofvariationinradiomicfeaturesextractedfrommulti-b-value DWI images.The featuresderivedfromnearbyb-value DWIhave higherrepeatibilty.GLRLM-RLNUN，GLCM-J.Entropy， GLCM-SumEntropy，IH-EntropyandGLDM-DNUNcanbeservedasnon-invasive biomarkers fordiagnosisof liverciosis. [Key words] Liver cirrhosis;Radiomics;Difusion weighted imaging;Magnetic resonance imaging

肝硬化是多种慢性肝病进展至以慢性炎症、弥漫性纤维化、假小叶形成、肝内外血管增殖为特征的病理阶段，早期诊断至关重要[1-2]。（剩余10540字）