动脉自旋标记对急性缺血性脑卒中早期神经功能衰退的预测价值

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[Abstract]Objective：Toevaluatethepredictionvalueofarterialspin labeling（ASL）toearlyneurologicaldeterioration（END） inpatientswithacuteischemicstroke（AIS）.Methods：Atotalof198AISpatientswereselected.According totheNational Institutesof Health Stroke Scale（NIHSS）score，198AIS patientsweredividedintoENDgroup（68cases）and non-END group（13Ocases）．Univariateandmultivariatelogisticanalyseswereperformedtoanalyzetheinfluencing factorsforEND inAISptients.ROCcurveswereploted toevaluatethepredictivevalue.Results：There were significantdiferencesinage， gender，NIHSSscore，lowperfusionvolumeatdiferntpostlabelingdelays（PLD）time（PLDof1.5，2.5s）andhypoperfusion volume ratio （HVR）between the two groups （all P<0.05 ）.Univariate logistic analysis showed that age，gender，NIHSS score， lowperfusionvolumeat1.5sPLDand2.5sPLD，andHVR were theinfluencingfactorsforEND（all P<0.05 ）.Multivariate logisticanalysisshowedthatage，lowperfusionvolumeat1.5sPLDand2.5sPLD，andHVRwereindependentriskfactors for END（all P <0.05），whlie NIHSS score was the protective factor（ P<0.001 ）．AUC values of age，NIHSS score，low perfusionvolumeat1.5sPLDand2.5sPLD，andHVRwere0.672，0.702，0.701，0.722and0.902 inpredictingEND inAIS patients.Conclusions：Age，NIHSSscore，lowperfusionvolumeat1.5sPLDand2.5sPLDandHVR have predictivevalue forEND in AIS patients，and HVR has the highest predictive value.

[Keywords] Arterial spin labeling;Stroke;Nerve function;Magnetic resonance imaging

急性缺血性脑卒中（acuteischemic stroke，AIS）是全世界第二大死亡原因，每年死亡人数约550万，也是致残的主要原因，约 50% 的幸存者有慢性残疾[1]。（剩余7263字）