基于TBSS对常规MRI检查不同颅内表现结核患者脑白质改变的分析

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[Abstract]Objective：Toexplore thewhitemateralterationsandtheirimpactoncognitivefunctioninpatientswithdiferent brainMRIfeatures.Methods：Atotalof24patientswithintracranialtuberculosis（ITB）and26patientswithextracranial multi-organtuberculosis（EMTB），and25healthycontrols（HC）wereretrospectivelycolectedasITB，EMTBandHCroups. Applyingthetract-basedspatialstatistics（TBSS）ofDTI，thediferencesinfractionalanisotropy（FA）andmeandifusivity（MD） wereanalyzedamongthethreegroups.Partialcorelationanalysiswasused，ithageandgenderascovariates，thecorrelations betweenFA，MDvaluesinROIandthecognitivefunctionwereinvestigated.Results：Compared toHCgroup，EMTBgroup exhibitedlocalizedelevationofMDvalue，ITBgroupexhibitedwidespreadFAdecreasesandmoreextensiveMDincreases. ComparedtoEMTBgroup，ITBgroupshowedFAdecreasesandMD increases，with asmalerrangeof diferences between ITBgroupandHC group.There werenosignificantcorrelations betweenFAor MDvaluesandthecognitive function scores （both P>0.05 ）.Conclusions：Both ITB and EMTB patients exhibit changes in white matter that may afect cognitive function.EMTB patients may have microstructural lesions in the brain.

[Keywords] Tuberculosis;Magnetic resonance imaging;Tract-based spatial statistics

颅内结核（intracranialtuberculosis，ITB）是由结核分枝杆菌（mycobacterium tuberculosis，MTB）引起的最严重的肺外结核1，临床表现多样且不典型，早期难以明确诊断2]。（剩余7459字）