早期膝骨关节炎软骨 T2 -mapping成像定量分析与滑液中IL-1含量的相关性
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[Abstract] Objective：To explore the correlation between the articular cartilage T2 value measured by T2-mapping and IL-1 of synovialfluidinearlykneeosteoarthritis.Methods：Fortysixpatientswithearlykneeosteoarthritisunderwentconventional MRI and T2-mapping examinations. T2 values of cartilage on the load-bearing and non-load-bearing surfaces of the femur and themedialandlateralcondylesofthetibiawerecalculatedafterimagepost-processing.IL-1levelinsynovialfluidwas measured. The correlation between T2 value and IL-1level was analyzed.Results：Tvalues of cartilage on the load-bearing surfaces of the internal condyle of the femur were 40.51-54.43 ms，average of （47.87±2.77）ms，th ose on the non-load-bearing surfaces were 43.01-47.71 ms，average of （45.31±2.17）ms .T2values of cartilage on the load-bearing surfaces of the external condyle of the femur were 39.86-48.43 ms，average of （44.87±3.27）ms，th ose on the non-load-bearing surfaces were 44.31- （204 48.91 ms，average of （46.31±3.37）ms T2 values of cartilage of the medial condyle of the tibia were 39.49-51.21 ms，average of （46.31±2.67）ms， thoseof the lateral condyle of the tibia were 4O.59-46.71 ms，averageof （43.19±2.67）ms . IL-1 levels were36.66-72.82pg/mL，average of （54.76±30.05）pg/mL .T2values of cartilage on the load-bearing surfaces of the internal condyleofthefemurandTvaluesofcartilageofthemedialcondyleofthetibiawerepositivelycorrelatedwithIL-1 level in synovial fluid （r=0.849，O.848，both P<0.001 ），while other T2 values were not correlated with IL-1 （all P>0.05 ）. Conclusions ： The cartilage T2 value of articular on the load-bearing surfaces of the internal condyle of the femur and the medialcondyleofthetibiaarepositivelycorelatedwithIL-1levelinsynovialfluidT-mappingcanbeusedasa non-invasive test to predict the inflammatory degree and active stage of early osteoarthritis.
[Key words]Osteoarthritis，knee; T2 mapping;Interleukin-1;Magnetic resonance imaging
随着我国老龄人口增加，骨关节炎患者日益增多[1]，其主要症状为关节疼痛，而关节内炎症与临床疼痛症状相关，如炎症持续存在，会加快骨关节炎进展[2]。（剩余6309字）
