基于定量CT探讨绝经后T2DM患者发生肌少症的危险因素

打开文本图片集

[Abstract]Objective：Toinvestigatetherelationshipsbetwenabdominalfat，lumbarbonedensity（BMD）andsarcopeniain postmenopausal women with type 2diabetesmelitus（T2DM）basedonquantitative CT（QCT）．Methods：Theclinical and abdominal CTimaging dataof18Opostmenopausalwomenwith T2DM（T2DMgroup）and15Oage-matched non-diabetic patients （control group） were reviewed. According to the skeletal muscle index of L3 vertebra （SMI-L3）measured by CT，the twogroupsweredividedintosarcopeniasubgroupsandnon-sarcopeniasubgroups.Thediferencesofclinicalandimagingdata betwentheT2DMgroupandthecontrolgroupwerecompared.Thediferences inBMI，menopauseyears，diabetescourse， blood lipid，blood glucose，subcutaneous fat area （SFA），visceral fat area （VFA）and skeletal muscle areaof L3 vertebra （SMA-L3） between thesarcopeniasubgroupand thenon-sarcopeniasubgroup intheT2DM group were compared.Thecorrelation between the above statistically significant variables and SMI- L3 was analyzed. Binary logistic regression analysis of risk factors forsarcopenia inpostmenopausal womenwithTDM.Results：Thediferences inHbAlc，fasting bloodglucose，HDL，SFA，VFA， BMD，theratesofosteoporosisandsarcopeniabetweentheT2DMgroupandthecontrolgroupwerestatisticallysignificant（al P<0.05 ）.Inthe T2DM group，there were 78 cases of sarcopeniaand102cases of non-sarcopenia.There weresignificant differences in BMI，diabetes course，BMD，SFA，VFA，SMI- ⋅L3 between the sarcopenia subgroup and the non-sarcopenia subgroup in the T2DM group（all P<0.05 ）.The diabetes course wasnegatively correlated with SMI ⋅L3 ，whileBMI，BMD，SFA，VFA were positively correlated with SMI- L3 （all P<0.05 ）.Binary logistic regression analysis showed that the increased course ofdiabeteswasariskfactorforsarcopenia，whiletheincreasedBMIandBMDweretheprotectivefactors.Conclusions： Postmenopausalwomenwith T2DMaremore likelytodevelopsarcopeniaandabdominalfataccumulation.Anincreased courseof diabetesisarisk factorforsarcopeniainpostmenopausalwomen，whilehighBMIandBMDare protectivefactors. [Keywords]Posmenopausal;Dabetesmelius，type2;arcopenia;Visceralfatarea;Bonemineraldensity;Tomography，-ray computed

2型糖尿病（type2 diabetes mellitus，T2DM）是由于胰岛素分泌不足或胰岛素抵抗作用引起血糖升高的慢性代谢性疾病。（剩余6789字）