两种血塞通软胶囊与三七粉抗血栓作用的对比研究

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【关键词】血塞通软胶囊；三七粉；血栓；角叉菜胶；电刺激；二磷酸腺苷二钠；胶原－肾上腺素 【中图分类号】R285.5 【文献标志码】A 【文章编号】1007－8517（2025）20-0023-04 DOI： 10.3969/j .issn.1007-8517.2025.20.zgmzmjyyzz202520006

Abstract：Objective Tocompare theantithrombotic efects of two kindsof Xuesaitong soft capsuleand Panax notoginseng powder.Methods Male ICR mice were randomly divided into 8 groups： vehicle，positive controls including 20 mg/kg of ASP， 1.0g/kg and 0.5g/kg of Panax notoginseng powder， 100mg/kg and 50 mg/kg of Luotai， 80mg/kg and 40 mg/kg of Lixuwang；The antithromboticfectsoftwoindsofXuesatongsoftcapsulesandPanaxnotognsengpowderwerecomparedthoughcarrageenaduced micetailthrombusmodel，electricstimulationofcarotidarterythrombusmodel，adenosinediphosphate（ADP-2Na）iducedacute pulmonarythrombusmodelandcollgene-adrenalintrombusmodelResultsInthecarrgeean-inducedcudal thrombusmodel， all administration groups had significant inhibitory effects on the formation of caudal thrombus（ P<0.01 ）．However，Panax notoginseng powder had no significant effect onthe prolongation ofcarotid artery thrombosis induced byelectricalstimulation （ P>0.05 ），and the prolongation rates of the two Xuesaitong soft capsules were all greater than 100% ，and the effect was significant （ P<0.05 ）.In thecollgen-adrenegineiducedthrombosismodel，thesurvivalratesoficeinLuotaiandLiuwanggroupswereallgeateran （204 50% ，and the effect was significant （ P<0.01 or P<0.05 ），while the survival rate of mice in Panax notoginseng powder group was only 25% ，the effect was not obvious （ P>0.05 ）．In the ADP -2 Na-induced acute pulmonary thrombosis model，the Luotai high dose group had the best protective effect，and the survival rate was 70.6% （ P<0.01 ），while the effect of Panax notoginseng powder powder was not significant （ P>0.05 ）.Conclusion Both Xuesaitong soft capsules and Panax notoginseng powder had antithrombotic effects，and the former was slightly better than the latter.

KeyWords：XuesaitongSoftCapsule；Panax Notoginseng Powder；Thrombus；Carrageenan；Electric Stimulation；Adenosine Diphosphate；Collagene-Adrenalin

缺血性心脑血管疾病是严重危害人类健康的疾病之一，而血栓形成是该类疾病共同的病理机制，也是重要的致病因素[1]。（剩余5570字）