阿利西尤单抗联合阿托伐他汀对顽固性高脂血症患者血脂水平及超敏C反应蛋白的影响

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中图分类号：R589.2 文献标识码：A文章编号：1006-1959（2025）15-0047-05

DOI：10.3969/j.issn.1006-1959.2025.15.009

Effect of Alirocumab Combined with Atorvastatinon BloodLipidLeveland High-sensitivity C-reactive Protein in Patientswith RefractoryHyperlipidemia

LONGTao，DENGQiong，WANG Shicheng （TheSecond Departmentof Internal Medicine，Wanzai County HospitalofTraditional Chinese Medicine， Wanzai，Jiangxi，China）

Abstract：ObectieTessthofloabdihoastatilodlipidlelandsiteacioe patientswithrefractoryhyperlipidemiaMetodsAtotalf66patientsithrefractoryhyperlipidemiaadmitedtanaiCountyHospitalf TraditionalChineseMedicinefromJauary22toJauaryO24wereseletedasthereseachbjectsAcordingtotherandomnumbertable method，theyeeddedtootolodseatioitatitsinchouTheotrolgopasreatedisati oraly，andtheatiooareatedittoastatiobditloabetioecallodlidlees [ile（ factor levels [tumor necrosis factor- ∇⋅α∝ （TNF- -α ），high-sensitivity C-reactive protein （hs-CRP），interleukin-6 （IL-6），hemorheology （plasma viscosity， wholebloodloutvisosityolelodigutvisositymatorit），deseeactiosalaninaiotrasferase（ae aminotrasfesad Results The total efective rateof the observation group was higher than that of thecontrol group（ P<0.05） .Aftertreatment，the levels of TG，LDL-C andTCntheobservationgroupwerelowerthantoseinthecontrolgroup，hiletelevelofHDL-Cwashigherthanthatinthecontrolgoup（ P< （2 0.05）.Thelevelsof inflammatory factors in theobservation group werelower than thosein thecontrol group（ P<0.05 ）.Theplasmaviscosity，whole bloodlowshearviscosityoleblodighearviscositydmatoitinthbsevatiogroupereowerthantoseiteotolgoup P< 号 0.05）.There was no significant diference in the incidence of adverse reactions between the two groups（ P> 0.05）.Conclusion Alirocumab combined withatorastaiflcaltiatfsicolearoodlde hemorheologylevelofpatients，reducetheirinflammatoryresponse，ndhashighsafety.Itisworthyofclinicalapplication.

Keywords：Alirocumab;Atorvastatin;Refractory hyperlipidemia; Bloodlipid;High-sensitivityC-reactiveprotein

顽固性高脂血症是临床常见的内分泌疾病，其发病与遗传、饮食、肥胖、饮酒、吸烟等因素有关，主要是由脂蛋白代谢紊乱引起的血脂指标异常，随着病情进展患者会出现出黄色瘤、眼底变黄、头晕、肢体乏力等症状[2]。（剩余5401字）