基于系统评价研究羟苯磺酸钙对ACEI治疗早期糖尿病肾病增效作用的规律

打开文本图片集

中图分类号：R587.2；R692.9 文献标识码：A文章编号：1006-1959（2025）15-0021-06

DOI：10.3969/j.issn.1006-1959.2025.15.004

Study on the Lawof Synergistic Effect of Calcium Dobesilate Combined withACEI in the Treatment ofEarlyDiabeticNephropathyBased ontheSystematicEvaluation

LIJiaol²，TANGZiliang1，XUJinlong²，TANGLi³，MAWeicheng2 （1.College ofPharmaceutical Science，Dali University，Dali 671ooo，Yunnan，China; 2.Departmentof Clinical Medicine，Ningbo UrologyNephrologyHospital，Ningbo 3151oo，Zhejiang，China; 3.DepartmentofKidney Transplantation，NingboUrology Nephrology Hospital，Ningbo315Oo，Zhejiang，China）

Abstract：ObjetieTostudteofsygsticftofalobesilatecombedithceiintetreatmentofarlyabetiot basedontheseaticauatioethodsdoedotroledialsCsereacedifangDataVued EmbaseandCocaneLraryabseptiotruarliteaesattiteeed，tataeeacedd evaluated.ThensstematiceauationasefoedyRevan.4sofareResultsElevetudieswith410patientsereicludedesuls of meta-analysis showed that The △urinary microalbumin （△mAlb）（ P =0.0006）and △urinary albumin excretion rate （△UAER）（P=O.O2） in the experimentalgouprehigherthantoseintheotrolgoup.eresultsofsubgopassowdintesofducinguriarycoalin calciudobalaalo mg dose group （ P< 0.01），ndthesegisticectofenazeprilOmgdosegroupasalsosignificantlybetertanthatofealaprilgdoeoup （ P <0.01）buttictoftooossilaidingayeetelsilted syeristicll 10 mg dose group，and both were better than perindopril 4 mg dose group （ P< 0.01）.Conclusion Calcium dobesilate has a certain synergistic effect on ACEIinthetreatfrleicotydeetstulsuotgeedoa

KeyWords：Calcium dobesilate;ACEI; Early diabetic nephropathy;Synergism effect

糖尿病肾病（diabetic kidneydisease，DKD）是糖尿病常见的一种微血管疾病，会增加糖尿病患者的发病率和死亡率，是全球终末期肾脏疾病（end-stagerenaldisease，ESRD）的主要病因[]。（剩余6653字）