基于网络药理和分子对接分析槲皮素治疗类风湿关节炎的作用机制

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中图分类号：R593.22 文献标识码：A文章编号：1006-1959（2025）15-0001-08

DOI：10.3969/j.issn.1006-1959.2025.15.001

Mechanism of Quercetin in the Treatment of Rheumatoid Arthritis Based on Network Pharmacology and Molecular Docking Technology

YANG Jingnan，LIYuxia，LINXuhong

（Centerfor Translational Medicine，DepartmentofLaboratoryMedicine，HuaiheHospitalofHenan University，

Kaifeng475000，Henan，China）

Abstract：ObjectieTalyeehofecetiiraetofmatdtisyetkaldlaog techologyesctitafdodteleseee TargetPredictdaasladsbsdes infomationmaptoolsuedtbainteoogetsfquecetidRAlatedtargetseproteroteniteractio（etok wasconstructedringdeeoteseedyyoafaretesetioespod databaseforGfuctioadKEGGatyichentaalsTegensoteotsigificantencmentpatayereoverlapedwihep 10targetsfdieosulesodied ThroughCytosaas9echC，GFReotk whichtheendocrinesistancepathayasteostsignifcantBycomparingteighttargetgnesoteendocinesistancepathaywihte firstentargetgsielapgseaelyC、ATFEGFR9.eolecig andquercetinshowedgoodbindingactivity.ConclusionQuercetinmayregulateSRCand MMP9 inestrogenpathwaybyregulating E2 level， further actontyrosineinasetrasmembanereceptorsIGF1RandEGFR，ndselectivelyregulateMAPKpathayandP3K/AKTpathaytoeatRA.

KeyWords：Quercetin;Rheumatoid arthritis;Network pharmacology;Molecular docking;Endocrine resistance

类风湿关节炎（rheumatoidarthritis，RA）是一种发病机制和病因尚未完全明确的自身免疫性疾病，目前认为其发病机制与性别、遗传、环境和免疫等因素有关。（剩余10254字）