基于网络药理学与分子对接探析肝升肺降散治疗支气管哮喘的作用机制

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中图分类号：R285 文献标识码：A文章编号：1006-1959（2025）15-0009-07

DOI：10.3969/j.issn.1006-1959.2025.15.002

Mechanism of Gansheng Feijiang Powder in the Treatment of Bronchial Asthma Based onNetworkPharmacologyandMolecularDocking

HETengfei¹，SUNXue²，ZHANGChangxi²，WUTong1 （1.CollegeofTraditional ChineseMedicine，NingxiaMedicalUniversity，Yinchuan75oo4，Ningxia，China;2.DepartmentofPulmonaryDisease，NingxiaMedicalUniversityAfliatedAutonomousRegionTraditionalChineseMedicineHospital/NingxiaHuiAutonomousRegionHospitalofTraditionalChineseMedicine/NingxiaHuiAutonomousRegionAcademyofTraditional Chinese Medicine，Yinchuan ，Ningxia，China）

AbstractOjectieTexploeeetieompontsndpotetialtargetsofasngFejaoderintetreamentofroalst （BA）bynetwokpharmacologndmoleculardocking，sostoprovidetheoreticalbssforitsapplcationintraditioalCnesedicine. MethodsThefectivecomponentsndtargetsofGnshengFejiangPowderereobtaiedfroTMSPdatabaseandtransfoedintognas byUniProtTeeaediseasetesereetrieeddeVeagaateteentesetiogesApoeotn interaction（oscedifeoddd enrichentanalysisaspfoAutoocksoftareasedforeulardocingtvauatetdingfoebetwencmponsdaets ResultsGanshgFejingoweroaid3ctieompontsd3itesetioargetsoreargetsicudL6 IL1B，TP53，PG2PndSGOfuctioalichealysissowdthatitivoledolgicalproesesschse exogeousstiidal signalingataidbdaeds active ingredients such as quercetin，kaempferol， β -sitosterol，stigmasterol and isorhamnetin can regulate targets such as PTGS2，MMP9 and TP53， participate in multiple key pathways，and thus play a therapeutic role in BA.

KeyWords：Bronchial asthma;Molecular docking;Network pharmacology;Gansheng FeijiangPowder

支气管哮喘（bronchialasthma，BA）是一种常见的慢性肺部疾病，与中医的“哮喘"概念相符合，其特征性症状包括间歇性呼吸困难、胸闷和咳嗽[1]。（剩余8147字）