血清GH、IGF-1与矮小症患儿微量元素、体格发育指标的相关性

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Correlation between Serum GH，IGF-1and Trace Elements and Physical Development Indicators in Children with Short Stature/HUANG Jie，ZHUYougen，YILi.//Medical InnovationofChina，2025，22（19）： 158-161

[Abstract]Objective： To explore the corelations between serum growth hormone （GH）， insulin-like growth factor-1（IGF-1）and trace elements and physical development indicators in children with short stature.Method：A total of 128children with short stature admited to from January 2O21 to December 2023 were selected as the observation group，and another 5O healthy children who underwent physical examinations during the same period were selected as the control group.The levels of GH，IGF-1，blood trace elements （calcium， magnesium，zinc，vitamin D）andphysical development indicators （height，weight，BMI，leptin，osteocalcin）of the two groups were compared.Pearson correlation coefcient analysis was used to explore the correlations between the levels of GHand IGF-1 inchildren with short stature and trace elements as well as physical development indicators. Result：The levels of serum calcium，magnesium，zinc，vitamin D，GHand IGF-1 in the observation group were significantly lower than those in the control group （ P <0.05）.The height，weight，BMI，levelsof leptinand osteocalcin in the observation group were significantly lower than those in the control group （ P <0.05）.Pearson correlation analysis showed that GHand IGF-1levels were positively correlated with serum calcium，magnesium，zinc，vitamin D，height，weight，BMI，leptin，and osteocalcin（ P <0.05）.Conclusion：Blood trace elements are closely related to thelevels ofGHand IGF-1，and havean important influenceon the growth anddevelopmentofchildren with short stature.Increasing the levels oftrace elements may help improve the growthand development status ofchildren with short stature，providing a reference basis for clinical intervention.

[Key words]Short statureBlood trace elementsGrowth hormoneInsulin-like growth factor-1Growth development

First-author'saddress：LaboratoryDepartment，， 336ooo，China doi：10.3969/j.issn.1674-4985.2025.19.036

矮小症是小儿内分泌科常见的发育障碍疾病，其主要临床表现为身高明显低于同龄儿童，伴随体重增长缓慢，甚至出现体格发育延迟的现象[1-2]。（剩余4203字）