氟西汀联合生物反馈疗法治疗青少年抑郁症的效果及对认知功能的影响

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Effectof Fluoxetine Combined with Biofeedback Therapyon Adolescent Depressonand Its Influence on Cognitive Function/XUE Qian.//Medical Innovation of China，2025，22（19）：108-111

[Abstract]Objective：To investigate the effect of Fluoxetine combined with biofeedback therapy in the treatment of adolescent depressionand its influence oncognitivefunction.Method：Atotalof8O patients with adolescentdepression admitted to the Second People's Hospitalof Guizhou Provincefrom January 2O22 to July 2024 were selected.All the research subjects were evenly divided into two groups bythe random number table method， namely the control group （ n =40，treated with Fluoxetine） and the observation group（ n =40，treated with Fluoxetine combined with biofeedback therapy）.Both before and afterthe treatment，the HAMD was used to assessthe severity of depression in the patients，and the Wisconsin card sorting test （WCST） wasused to evaluate the cognitive function of the patients.The clinical efficacy of thetwo groups was observed.Result： After treatment，the HAMD scores of both groups decreased significantly，and that of the observation group was lower than thatof the control group，the differences were statistically significant （ P <0.05）.In the WCST tests after treatment in both groups，the number of completed classfications increased， while the number of incorrect responses，persistent erors and non-persistent errors decreased，the improvementof each result inthe observation group was more obvious than thatin the control group，the differences were statistically significant （ P <0.05）. The curative effect of the observation group was better thanthat of thecontrol group，thedifferencewas statisticallysignificant （ P <0.05）.Conclusion： The combination of Fluoxetine and biofeedback therapy has a beter effect on the treatment of adolescent depression， which can improve the clinical efficacy，the degree of depression and cognitive function of patients.

[Key words] Adolescent Depression Fluoxetine Biofeedback Cognitive function

First-author's addres： Department of Psychiatry，the Second People's Hospital of Guizhou Province， Guiyang 550001， China doi：10.3969/j.issn.1674-4985.2025.19.025

青少年抑郁症作为一种日益受到关注的心理健康问题，其发病率逐年上升，对青少年的身心健康、学业成就及社交关系产生了深远的影响[1]。（剩余5479字）