贝伐珠单抗联合TP方案化疗对晚期子宫颈癌 患者血清肿瘤标志物及不良反应的影响

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The Influence of Bevacizumab Combined with TP Regimen Chemotherapy on Serum Tumor Markers and Adverse Reactions inPatients with Advanced Cervical Cancer/， .// Medical Innovation of China，2025，22（19）： 010-014

[Abstract]Objective： To explore the effcts of Bevacizumab and TP regimen （Paclitaxel plus Cisplatin） chemotherapy onserum tumor markers and adverse reactions in patients with advancedcervical cancer.Method： A total of 86 patients with advanced cervical cancer admited to Fengcheng People's Hospital from June2O21 to December 2023 were selected as the subjects.They were divided into two groups according to the random number table method， with 43 cases in each group.The control group was treated with the TP regimen， while the observation group was treated with Bevacizumabinaddition to thecontrol group.Theclinical eficacy，serum tumor markers，Tcellsubsets， tumor diameter，qualityof life and adverse reactions of thetwo groups were compared.Result： After treatment，the total effective rate of the observation group was higher than that of the control group （ P <0.05）.After treatment， the levels of carbohydrate antigen 19-9 （CA19-9），carcinoembryonic antigen （CEA），squamous cell carcinoma antigen （SCC-Ag），cytokeratin 19 fragment （Cyfra 21-1），and carbohydrate antigen 125 （CA125） in the observation group were lower than those in the control group （ P <0.05）.Aftertreatment， thelevelsof Th1and Th2and Th1/Th2 in the observation group were all lower than those in the control group （ P <0.05）.After treatment，the tumor diameter in the observationgroup wassmaler than that in thecontrol group，and theoverallimprovementof the qualityof life in the observation group was better than that in the control group （ P <0.05）. Regarding adverse reactions， there was no statistically significant difference between the two groups （ P>0.05 ）.Conclusion：The combination of Bevacizumab andthe TP regimen can efectively improvethe levels of serum tumor markersand Tcellsubsets in patients with advanced cervical cancer，reduce the tumor diameter，improve the qualityof life，and does not increase obvious adverse reactions，with relatively high safety.

子宫颈癌是一种妇科恶性肿瘤，在临床较为常见，原发于子宫颈，发病率及病死率高[-2]。（剩余5741字）