柴胡疏肝散加减治疗非酒精性脂肪性肝病的 临床效果及对脂代谢的影响

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Clinical Effectof Modified Chaihu Shugan Powder in the Treatmentof Non-alcoholic FattyLiver Disease and Its Influence onLipidMetabolism/CENFenglan，ZHANG Sirong，YANG Xiaopeng.//Medical Innovation ofChina，2025，22（19）：036-040

[Abstract]Objective：To explore the clinical efect of modified Chaihu Shugan Powder in the treatmentof non-alcoholic fatty liverdisease （NAFLD）and its influence on lipid metabolism.Method： Aretrospective analysis was conductedon1OOpatientswithNAFLDwho were diagnosedand treated inYangjiang Hospitalof Traditional Chinese Medicine from December 2O23 to November 2024.According to the different treatment plans adopted， they were divided into the conventional group and the combined group.The conventional group （n=5O）was given conventional intervention （diet control， lifestyle change + oral administration ofPolyene Phosphatidylcholine Capsules），and the combined group （ n =50） was treated with modified Chaihu Shugan Powder on the basis of the conventional group.Thetreatment course for both groupswere2 months.After treatment，the therapeutic effects of thetwo groups were evaluated，thelaboratory indicators （liver functionand lipid metabolism）and qualityof life before and aftertreatment inthe two groups were compared，andthesafetyofthe treatment were evaluated.Result：The total effective rate of the combined group was higher than that of the conventional group （ P <0.05）. Before treatment， there were no statistically significant differences in liver function and lipid metabolismlevels between the two groups （ P> 0.05）.After treatment，the liver function and lipid metabolism levels in the combined group were significantly better than those in the conventional group（ P <0.05）.Before treatment，there were no statistically significant differences in the quality of life scores between the two groups （ P- >0.05）.After treatment， the scores of activity， emotion and fatigue in the combined group were higher than those in the conventional group （ P <0.05）. No serious adverse reactions occurred in both group during the two-month treatment process.Conclusion： Modified Chaihu Shugan Powder is used inthe clinical treatmentof NAFLD，which can enhance the therapeutic efect，improvethe liver function and lipid metabolism of patients，and improve the quality of life.

非酒精性脂肪性肝病（non-alcoholic fattyliverdisease，NAFLD）作为代谢综合征的肝脏表征，其患病率随生活方式改变呈显著上升趋势，已成为全球慢性肝病的重要病因[]。（剩余5786字）