单细胞测序技术揭示TNBC中成纤维细胞作用的研究进展

[关键词]三阴性乳腺癌；单细胞测序技术;癌相关成纤维细胞;综述[中图分类号]R737.9 [文献标志码］A [文章编号] 2096-5532（2025）05-0777-05doi：10.11712/jms.2096-5532.2025.61.138 [开放科学（资源服务）标识码（OSID）][网络出版] https：//link.cnki.net/urlid/37.1517.R.20251011.1358.002; 2025-10-1314：31：49

Research progresinsudingteoleofanerassociatedfibroblastsintrieegativebreastcncerusingsiglecellsequeingtch nologyXIAO Han，WANG Li，HUANG Guofu，LENG Xiaoling（Department of Oncology，Fifth Afiliated Hospital of Xinjiang Medical University，Urumqi 830o0o，China）

[Abstract]Cancer-associated fibroblasts（CAFs）arethemostimportantandabundantstromalcelsinthetumormicroenvironment（TME），exhibitinghighheterogeneityandparticipatingextensivelyinvariousbiologicalbehaviorsoftumors.Singlecel sequencing（sRNA-seq）isanovel technologythatalows genomic，transcriptomicandepigeneticanalysisatthesinglecellevel， which provides unprecedented advantages foradeepunderstandingofTME，CAFsubtypes，and thefunctionofspecific CAF subpopulations.Thisarticlebrieflyintroduces theprinciplesandapplicationofscRNA-seq，withafocus onsummarizingrecntadvances on its use for studying the role of CAFs in triple-negative breast cancer.

[Key words]triple negative breast neoplasms；single-cellsequencing technology；cancer-associated fibroblasts；review

乳腺癌为女性群体中最普遍的恶性肿瘤之一，其中三阴性乳腺癌（TNBC）的病情尤为严峻。（剩余14276字）